Nuvenzepine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 527203

CAS#: 96487-37-5

Description: Nuvenzepine is a musccarinic M3 antagonist used to treat gastrospasm.


Price and Availability

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Nuvenzepine is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 527203
Name: Nuvenzepine
CAS#: 96487-37-5
Chemical Formula: C19H20N4O2
Exact Mass: 336.1586
Molecular Weight: 336.395
Elemental Analysis: C, 67.84; H, 5.99; N, 16.66; O, 9.51


Synonym: Nuvenzepine; Nuvenzepinum;

IUPAC/Chemical Name: 11-(1-methylpiperidine-4-carbonyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one

InChi Key: HPKYRXAEGNUARA-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20N4O2/c1-22-11-8-13(9-12-22)19(25)23-16-7-3-2-6-15(16)21-18(24)14-5-4-10-20-17(14)23/h2-7,10,13H,8-9,11-12H2,1H3,(H,21,24)

SMILES Code: O=C1C2=CC=CN=C2N(C(C3CCN(C)CC3)=O)C4=CC=CC=C4N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Barocelli E, Ballabeni V, Chiavarini M, Molina E, Impicciatore M. Functional comparison between nuvenzepine and pirenzepine on different guinea pig isolated smooth muscle preparations. Pharmacol Res. 1994 Aug-Sep;30(2):161-70. PubMed PMID: 7816744.

2: Caselli G, Ferrari MP, Tonon G, Clavenna G, Borsa M. Determination of nuvenzepine in human plasma by a sensitive [3H]pirenzepine radioreceptor binding assay. J Pharm Sci. 1991 Feb;80(2):173-7. PubMed PMID: 2051325.

3: Barocelli E, Chiavarini M, Gentile A, Lavezzo A, Impicciatore M. Gastrointestinal activities of a new pirenzepine-analog, nuvenzepine, in the cat. Farmaco. 1990 Oct;45(10):1089-99. PubMed PMID: 2095154.

4: Barocelli E, Ballabeni V, Chiavarini M, Caretta A, Molina E, Impicciatore M. Regional differences in motor responsiveness to antimuscarinic drugs in rabbit isolated small and large intestine. Pharmacol Res. 1995 Jan;31(1):43-8. PubMed PMID: 7784305.

5: Novelli F, Sparatore A, Tasso B, Sparatore F. Quinolizidinyl derivatives of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one as ligands for muscarinic receptors. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3031-4. PubMed PMID: 10571170.

6: Barocelli E, Ballabeni V, Chiavarini M, Molina E, Lavezzo A, Impicciatore M. Muscarinic M1 and M3 receptor antagonist effects of a new pirenzepine analogue in isolated guinea-pig ileal longitudinal muscle-myenteric plexus. Eur J Pharmacol. 1994 Mar 11;254(1-2):151-7. PubMed PMID: 7515819.

7: Barocelli E, Morini G, Ballabeni V, Lavezzo A, Impicciatore M. Effects of two new pirenzepine analogs on the contractile response of the guinea-pig oesophageal muscularis mucosae to acetylcholine, bethanechol, histamine and high potassium. Eur J Pharmacol. 1990 Apr 10;179(1-2):89-96. PubMed PMID: 1973103.

8: Eltze M, Mutschler E, Lambrecht G. Affinity profiles of pizotifen, ketotifen and other tricyclic antimuscarinics at muscarinic receptor subtypes M1, M2 and M3. Eur J Pharmacol. 1992 Feb 18;211(3):283-93. PubMed PMID: 1377628.