Vintoperol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530014

CAS#: 106498-99-1

Description: Vintoperol is a calcium channel antagonist potentially for the treatment of arterial occlusive disease and peripheral artery disease.

Chemical Structure

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Vintoperol
CAS# 106498-99-1
Instruction

Theoretical Analysis

MedKoo Cat#: 530014
Name: Vintoperol
CAS#: 106498-99-1
Chemical Formula: C18H24N2O
Exact Mass: 284.19
Molecular Weight: 284.400
Elemental Analysis: C, 76.02; H, 8.51; N, 9.85; O, 5.63

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Vintoperol, RGH-2981, RT-3003, RGH2981, RT3003, RGH 2981, RT 3003

IUPAC/Chemical Name: ((1S,12bS)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl)methanol

InChi Key: BKRBRZLECKMEBD-QZTJIDSGSA-N

InChi Code: InChI=1S/C18H24N2O/c1-2-18(12-21)9-5-10-20-11-8-14-13-6-3-4-7-15(13)19-16(14)17(18)20/h3-4,6-7,17,19,21H,2,5,8-12H2,1H3/t17-,18-/m1/s1

SMILES Code: CC[C@]1(CO)CCCN2[C@@H]1C3=C(C4=CC=CC=C4N3)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 284.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yoshitsugu H, Fukuhara T, Ishibashi M, Nanbo T, Kagi N. Key fragments for identification of positional isomer pair in glucuronides from the hydroxylated metabolites of RT-3003 (Vintoperol) by liquid chromatography/electrospray ionization mass spectrometry. J Mass Spectrom. 1999 Oct;34(10):1063-8. PubMed PMID: 10510429.

2: Csomor K, Kárpáti E. Effect of vintoperol on platelet aggregation and experimental thrombosis. Arzneimittelforschung. 1994 Jan;44(1):36-40. PubMed PMID: 8135876.

3: Tkachenko MN, Sagach VF, Bazilyuk OV, Shapoval MV. Involvement of endothelium in vasodilating effects of vintoperol. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S90-3. PubMed PMID: 1282997.

4: Sahach VF, Tkachenko MM, Bazyliuk OV. [The role of the endothelium in the vascular effects of vintoperol]. Fiziol Zh. 1992 May-Jun;38(3):32-9. Ukrainian. PubMed PMID: 1499759.

5: Xu R, Liu N, Xu X, Kong B. Antioxidative effects of whey protein on peroxide-induced cytotoxicity. J Dairy Sci. 2011 Aug;94(8):3739-46. doi: 10.3168/jds.2010-3891. PubMed PMID: 21787910.

6: Szombathelyi Z, Kárpáti E, Kalaus G, Szabó L, Szántay C. Vasodilator and angioprotective activity of 1-ethyl-1-hydroxyalkyl-octahydroindolo[2,3a]quinolizine derivates. Arzneimittelforschung. 1991 Jun;41(6):621-5. PubMed PMID: 1930350.

7: Kárpáti E, Bíró K, Kukorelli T. [Investigation of vasoactive agents with indole skeletons at Richter Ltd]. Acta Pharm Hung. 2002;72(1):25-36. Hungarian. PubMed PMID: 12426785.

8: Kaburagi T, Yoshitsugu H, Uekusa H, Ishibashi M, Nanbo T. Identification and clearance involved in the formation of glucuronides of RT-3003, a new peripheral blood flow enhancer, and its metabolite in rats. Biol Pharm Bull. 2000 Jan;23(1):128-31. PubMed PMID: 10706427.

9: Szombathelyi Z, Kárpáti E, Till A. Comparative in vitro study of RGH-2981, a new peripheral blood flow enhancer on animal and pathological human arteries. Pol J Pharmacol Pharm. 1989 Nov-Dec;41(6):591-5. PubMed PMID: 2485906.