WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530012
CAS#: 827319-43-7
Description: GW-870086 is a glucocorticoid receptor agonist potentially for the treatment of asthma and atopic dermatitis.
MedKoo Cat#: 530012
Name: GW-870086
CAS#: 827319-43-7
Chemical Formula: C31H39F2NO6
Exact Mass: 559.27
Molecular Weight: 559.65
Elemental Analysis: C, 66.53; H, 7.02; F, 6.79; N, 2.50; O, 17.15
Synonym: GW-870086; GW-870086X; 870086; GW870086; GW870086X; GW 870086; GW 870086X
IUPAC/Chemical Name: Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-(((2,2,3,3-tetramethylcyclopropyl)carbonyl)oxy)-, cyanomethyl ester, (6alpha,11beta,16alpha,17alpha)-
InChi Key: WUBKGTSFJSEIEM-NSHBDUGJSA-N
InChi Code: InChI=1S/C31H39F2NO6/c1-16-12-18-19-14-21(32)20-13-17(35)8-9-28(20,6)30(19,33)22(36)15-29(18,7)31(16,25(38)39-11-10-34)40-24(37)23-26(2,3)27(23,4)5/h8-9,13,16,18-19,21-23,36H,11-12,14-15H2,1-7H3/t16-,18+,19+,21+,22+,28+,29+,30+,31+/m1/s1
SMILES Code: C[C@@]12[C@](C(OCC#N)=O)(OC(C3C(C)(C)C3(C)C)=O)[C@H](C)C[C@@]1([H])[C@]4([H])C[C@H](F)C5=CC(C=C[C@]5(C)[C@@]4(F)[C@@H](O)C2)=O
1: Uings IJ, Needham D, Matthews J, Haase M, Austin R, Angell D, Leavens K, Holt J, Biggadike K, Farrow SN. Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile. Br J Pharmacol. 2013 Jul;169(6):1389-403. doi: 10.1111/bph.12232. PubMed PMID: 23639214; PubMed Central PMCID: PMC3831715.
2: Bareille P, Hardes K, Donald AC. Efficacy and safety of once-daily GW870086 a novel selective glucocorticoid in mild-moderate asthmatics: a randomised, two-way crossover, controlled clinical trial. J Asthma. 2013 Dec;50(10):1077-82. doi: 10.3109/02770903.2013.837480. PubMed PMID: 23991670.
3: Stamer WD, Hoffman EA, Kurali E, Krauss AH. Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2100-7. doi: 10.1167/iovs.12-11298. PubMed PMID: 23462748; PubMed Central PMCID: PMC4601886.
4: Leaker BR, O'Connor B, Singh D, Barnes PJ. The novel inhaled glucocorticoid receptor agonist GW870086X protects against adenosine-induced bronchoconstriction in asthma. J Allergy Clin Immunol. 2015 Aug;136(2):501-2.e6. doi: 10.1016/j.jaci.2015.01.034. PubMed PMID: 25784273.
5: Dölle S, Hielscher N, Bareille PJ, Hardes K, Robertson J, Worm M. Clinical efficacy and tolerability of a novel selective corticosteroid in atopic dermatitis--two randomised controlled trials. Skin Pharmacol Physiol. 2015;28(3):159-66. doi: 10.1159/000367696. PubMed PMID: 25614148.
6: Cazzola M, Coppola A, Rogliani P, Matera MG. Novel glucocorticoid receptor agonists in the treatment of asthma. Expert Opin Investig Drugs. 2015;24(11):1473-82. doi: 10.1517/13543784.2015.1078310. Review. PubMed PMID: 26293110.
7: Rider CF, Shah S, Miller-Larsson A, Giembycz MA, Newton R. Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting β(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands. PLoS One. 2015 Jan 27;10(1):e0116773. doi: 10.1371/journal.pone.0116773. Erratum in: PLoS One. 2015;10(5):e0128728. PubMed PMID: 25625944; PubMed Central PMCID: PMC4308083.