UK 66914

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MedKoo CAT#: 526528

CAS#: 113049-11-9

Description: UK 66914 is a K(+)-channel blocker.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-30. Prices are subject to change without notice.

UK 66914 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 526528
Name: UK 66914
CAS#: 113049-11-9
Chemical Formula: C18H24N4O3S
Exact Mass: 376.1569
Molecular Weight: 376.475
Elemental Analysis: C, 57.43; H, 6.43; N, 14.88; O, 12.75; S, 8.52

Synonym: UK 66914, UK-66914, UK66914

IUPAC/Chemical Name: Methanesulfonamide, N-(4-(1-hydroxy-2-(4-(4-pyridinyl)-1-piperazinyl)ethyl)phenyl)-


InChi Code: InChI=1S/C18H24N4O3S/c1-26(24,25)20-16-4-2-15(3-5-16)18(23)14-21-10-12-22(13-11-21)17-6-8-19-9-7-17/h2-9,18,20,23H,10-14H2,1H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Rees SA, Vandenberg JI, Wright AR, Yoshida A, Powell T. Cell swelling has differential effects on the rapid and slow components of delayed rectifier potassium current in guinea pig cardiac myocytes. J Gen Physiol. 1995 Dec;106(6):1151-70. PubMed PMID: 8786354; PubMed Central PMCID: PMC2229303.

2: MacKenzie I, Saville VL, Waterfall JF. Differential class III and glibenclamide effects on action potential duration in guinea-pig papillary muscle during normoxia and hypoxia/ischaemia. Br J Pharmacol. 1993 Oct;110(2):531-8. PubMed PMID: 8242227; PubMed Central PMCID: PMC2175944.

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4: Gwilt M, Orme J, Rourke JD, Henderson CG. K(+)-channel blockers and coronary vasoconstriction in guinea-pig perfused hearts in-vitro. J Pharm Pharmacol. 1993 Jul;45(7):671-4. PubMed PMID: 8105068.

5: Rees SA, Curtis MJ. Selective IK blockade as an antiarrhythmic mechanism: effects of UK66,914 on ischaemia and reperfusion arrhythmias in rat and rabbit hearts. Br J Pharmacol. 1993 Jan;108(1):139-45. PubMed PMID: 8428204; PubMed Central PMCID: PMC1907696.

6: Gwilt M, Henderson CG, Orme J, Rourke JD. Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro. Eur J Pharmacol. 1992 Sep 22;220(2-3):231-6. PubMed PMID: 1425994.

7: Wallace AA, Stupienski RF 3rd, Brookes LM, Selnick HG, Claremon DA, Lynch JJ Jr. Cardiac electrophysiologic and inotropic actions of new and potent methanesulfonanilide class III antiarrhythmic agents in anesthetized dogs. J Cardiovasc Pharmacol. 1991 Nov;18(5):687-95. PubMed PMID: 1723765.

8: Baskin EP, Serik CM, Wallace AA, Brookes LM, Selnick HG, Claremon DA, Lynch JJ Jr. Effects of new and potent methanesulfonanilide class III antiarrhythmic agents on myocardial refractoriness and contractility in isolated cardiac muscle. J Cardiovasc Pharmacol. 1991 Sep;18(3):406-14. PubMed PMID: 1720841.

9: Gwilt M, Dalrymple HW, Burges RA, Blackburn KJ, Dickinson RP, Cross PE, Higgins AJ. Electrophysiologic properties of UK-66,914, a novel class III antiarrhythmic agent. J Cardiovasc Pharmacol. 1991 Mar;17(3):376-85. PubMed PMID: 1711597.