HMR-1426

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530140

CAS#: 262376-75-0

Description: HMR-1426 is gastric emptying inhibitor potentially for the treatment of obesity. In one study, HMR1426 showed an anorectic potential in rats and decreased body weight and fat mass. This was achieved solely by reducing food intake without influencing overall energy expenditure or behavior suggesting a peripheral mode of action. Thus, HMR1426 can be considered a potential new drug for obesity treatment.

Chemical Structure

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HMR-1426
CAS# 262376-75-0
Instruction

Theoretical Analysis

MedKoo Cat#: 530140
Name: HMR-1426
CAS#: 262376-75-0
Chemical Formula: C16H12ClNOS
Exact Mass: 301.03
Molecular Weight: 301.790
Elemental Analysis: C, 63.68; H, 4.01; Cl, 11.75; N, 4.64; O, 5.30; S, 10.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: HMR-1426; HMR1426; HMR 1426; 1426

IUPAC/Chemical Name: 6-chloro-2-phenyl-8,8a-dihydro-3aH-indeno[1,2-d]thiazol-3a-ol

InChi Key: RUBKYBIDEVUTQU-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12ClNOS/c17-12-6-7-13-11(8-12)9-14-16(13,19)18-15(20-14)10-4-2-1-3-5-10/h1-8,14,19H,9H2

SMILES Code: ClC(C=C1)=CC2=C1C(N=C(C3=CC=CC=C3)S4)(O)C4C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 301.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ortmann S, Kampe J, Gossel M, Bickel M, Geisen K, Jähne G, Lang HJ, Klaus S. The novel antiobesic HMR1426 reduces food intake without affecting energy expenditure in rats. Obes Res. 2004 Aug;12(8):1290-7. PubMed PMID: 15340112.

2: Bickel M, Gossel M, Geisen K, Jaehne G, Lang HJ, Rosenburg R, Sandow J. Analysis of the anorectic efficacy of HMR1426 in rodents and its effects on gastric emptying in rats. Int J Obes Relat Metab Disord. 2004 Feb;28(2):211-21. PubMed PMID: 14663491.