WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530377

CAS#: 147591-46-6

Description: ID-8 is a DYRK inhibitor. ID-8 could support Wnt-induced human embryonic stem cell proliferation and survival without differentiation. Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) is the target of the small molecule ID-8. Its role in human pluripotent cell renewal was confirmed by DYRK knockdown in human embryonic stem cells.

Chemical Structure

CAS# 147591-46-6

Theoretical Analysis

MedKoo Cat#: 530377
Name: ID-8
CAS#: 147591-46-6
Chemical Formula: C16H14N2O4
Exact Mass: 298.0954
Molecular Weight: 298.298
Elemental Analysis: C, 64.42; H, 4.73; N, 9.39; O, 21.45

Price and Availability

Size Price Availability Quantity
100.0mg USD 450.0 2 Weeks
200.0mg USD 750.0 2 Weeks
500.0mg USD 1250.0 2 Weeks
1.0g USD 2450.0 2 Weeks
2.0g USD 3950.0 2 Weeks
5.0g USD 5850.0 2 Weeks
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Synonym: ID-8; ID 8; ID8.

IUPAC/Chemical Name: 1-(4-methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol


InChi Code: InChI=1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3

SMILES Code: OC1=CC2=C(C=C1)C([N+]([O-])=O)=C(C)N2C3=CC=C(OC)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 298.298 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Sylvain V, Lafarge S, Bignon YJ. Molecular pathways involved in response to ionizing radiation of ID-8 mouse ovarian cancer cells expressing exogenous full-length Brca1 or truncated Brca1 mutant. Int J Oncol. 2001 Sep;19(3):599-607. PubMed PMID: 11494042.

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7: Tsuboi S, Miyashita T, Yamaguchi Y, Yamamoto Y, Sakamaki K, Goto T. The TaperGuard™ endotracheal tube intracuff pressure increase is less than that of the Hi-Lo™ tube during nitrous oxide exposure: a model trachea study. Anesth Analg. 2013 Mar;116(3):609-12. doi: 10.1213/ANE.0b013e318279b399. PubMed PMID: 23400983.

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9: Ahn YM, Vogeti L, Liu CJ, Santhapuram HK, White JM, Vasandani V, Mitscher LA, Lushington GH, Hanson PR, Powell DR, Himes RH, Roby KF, Ye Q, Georg GI. Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues. Bioorg Med Chem. 2007 Jan 15;15(2):702-13. PubMed PMID: 17123821; PubMed Central PMCID: PMC1876666.

10: Özkan NC, Ozkan F. The relationship of temporomandibular disorders with headaches: a retrospective analysis. Agri. 2011 Jan;23(1):13-7. PubMed PMID: 21341147.

11: Glenn IC, Bruns NE, Ponsky TA. Use of 5-mm Laparoscopic Stapler to Perform Open Small Bowel Anastomosis in a Neonatal Animal Model. J Laparoendosc Adv Surg Tech A. 2016 Oct;26(10):840-844. PubMed PMID: 27462959.

12: Fotiadou EG, Neofotistou KH, Giagazoglou PF, Tsimaras VK. The effect of a psychomotor education program on the static balance of children with Intellectual Disability. J Strength Cond Res. 2016 Aug 18. [Epub ahead of print] PubMed PMID: 27548783.

13: Hart KA, Wochele DM, Norton NA, McFarlane D, Wooldridge AA, Frank N. Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses. J Vet Intern Med. 2016 Mar-Apr;30(2):653-63. doi: 10.1111/jvim.13839. PubMed PMID: 26860336; PubMed Central PMCID: PMC4913614.

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15: Sharma P, Hosmer A, Appelman H, McKenna B, Jafri MS, Sullivan P, Fontana RJ, Lok AS. Immunological dysfunction during or after antiviral therapy for recurrent hepatitis C reduces graft survival. Hepatol Int. 2013 Oct;7(4):990-9. doi: 10.1007/s12072-013-9436-1. PubMed PMID: 25815091; PubMed Central PMCID: PMC4371864.

16: Garcia-Garcerà M, Coscollà M, Garcia-Etxebarria K, Martín-Caballero J, González-Candelas F, Latorre A, Calafell F. Staphylococcus prevails in the skin microbiota of long-term immunodeficient mice. Environ Microbiol. 2012 Aug;14(8):2087-98. doi: 10.1111/j.1462-2920.2012.02756.x. PubMed PMID: 22524615.

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100.0mg / USD 450.0