MS436
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MedKoo CAT#: 406976

CAS#: 1395084-25-9

Description: MS436 is a BRD4 inhibitor. MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated Ki of 30-50 nM). MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression.


Chemical Structure

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MS436
CAS# 1395084-25-9

Theoretical Analysis

MedKoo Cat#: 406976
Name: MS436
CAS#: 1395084-25-9
Chemical Formula: C18H17N5O3S
Exact Mass: 383.1052
Molecular Weight: 383.426
Elemental Analysis: C, 56.39; H, 4.47; N, 18.27; O, 12.52; S, 8.36

Price and Availability

Size Price Availability Quantity
10.0mg USD 150.0 2 Weeks
25.0mg USD 250.0 2 Weeks
50.0mg USD 450.0 2 Weeks
100.0mg USD 650.0 2 Weeks
200.0mg USD 1050.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 2850.0 2 Weeks
2.0g USD 3950.0 2 Weeks
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Synonym: MS436; MS-436; MS 436.

IUPAC/Chemical Name: (E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide

InChi Key: DZTGIRNXWSZBIM-QURGRASLSA-N

InChi Code: InChI=1S/C18H17N5O3S/c1-12-10-16(15(19)11-17(12)24)22-21-13-5-7-14(8-6-13)27(25,26)23-18-4-2-3-9-20-18/h2-11,24H,19H2,1H3,(H,20,23)/b22-21+

SMILES Code: O=S(C1=CC=C(/N=N/C2=CC(C)=C(O)C=C2N)C=C1)(NC3=NC=CC=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 383.426 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhang G, Plotnikov AN, Rusinova E, Shen T, Morohashi K, Joshua J, Zeng L,
Mujtaba S, Ohlmeyer M, Zhou MM. Structure-guided design of potent diazobenzene
inhibitors for the BET bromodomains. J Med Chem. 2013 Nov 27;56(22):9251-64. doi:
10.1021/jm401334s. PubMed PMID: 24144283; PubMed Central PMCID: PMC3894848.

MS436

10.0mg / USD 150.0