ALRT 1550

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531437

CAS#: 178600-20-9

Description: ALRT 1550 is a retinoic acid agent (RAR) agonist potentially for the treatment of cervical carcinoma.

Chemical Structure

ALRT 1550
CAS# 178600-20-9

Theoretical Analysis

MedKoo Cat#: 531437
Name: ALRT 1550
CAS#: 178600-20-9
Chemical Formula: C23H32O2
Exact Mass: 340.2402
Molecular Weight: 340.507
Elemental Analysis: C, 81.13; H, 9.47; O, 9.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: LG-1550; ALRT-1550; ALRT-550; LGD-1550; LG1550; ALRT1550; ALRT550; LGD1550; LG 1550; ALRT 1550; ALRT 550; LGD 1550

IUPAC/Chemical Name: (2E,4E,6E)-7-(3,5-ditert-butylphenyl)-3-methylocta-2,4,6-trienoic acid


InChi Code: InChI=1S/C23H32O2/c1-16(12-21(24)25)10-9-11-17(2)18-13-19(22(3,4)5)15-20(14-18)23(6,7)8/h9-15H,1-8H3,(H,24,25)/b10-9+,16-12+,17-11+

SMILES Code: C/C(C1=CC(C(C)(C)C)=CC(C(C)(C)C)=C1)=C\C=C\C(C)=C\C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 340.507 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mei JH, Wang MW. [Advances in studies on selective RXR ligands]. Yao Xue Xue Bao. 2005 Apr;40(4):294-8. Review. Chinese. PubMed PMID: 16011254.

2: Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schüle R. All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat Struct Biol. 2003 Oct;10(10):820-5. PubMed PMID: 12958591.

3: Hu W, Verschraegen CF, Wu WG, Nash M, Freedman RS, Kudelka A, Kavanagh JJ. Activity of ALRT 1550, a new retinoid, with interferon-gamma on ovarian cancer cell lines. Int J Gynecol Cancer. 2002 Mar-Apr;12(2):202-7. PubMed PMID: 11975681.

4: Shalinsky DR, Bischoff ED, Lamph WW, Zhang L, Boehm MF, Davies PJ, Nadzan AM, Heyman RA. A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice. Cancer Res. 1997 Jan 1;57(1):162-8. PubMed PMID: 8988059.

5: Zhang L, Nadzan AM, Heyman RA, Love DL, Mais DE, Croston G, Lamph WW, Boehm MF. Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells. J Med Chem. 1996 Jul 5;39(14):2659-63. PubMed PMID: 8709094.