WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 531409
CAS#: 865305-30-2
Description: AF353 is a P2X3 receptor antagonist. Antagonism of the P2X3 receptor is one of the potential therapeutic strategies for the management of neuropathic pain because P2X3 receptors are predominantly localized on small to medium diameter C- and Aδ-fiber primary afferent neurons, which are related to the pain-sensing system.
MedKoo Cat#: 531409
Name: AF353
CAS#: 865305-30-2
Chemical Formula: C14H17IN4O2
Exact Mass: 400.0396
Molecular Weight: 400.2205
Elemental Analysis: C, 42.02; H, 4.28; I, 31.71; N, 14.00; O, 8.00
Synonym: AF353; AF-353; AF 353.
IUPAC/Chemical Name: 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine
InChi Key: AATPYXMXFBBKFO-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19)
SMILES Code: NC1=NC=C(OC2=CC(I)=C(OC)C=C2C(C)C)C(N)=N1
1: Jung YH, Kim YO, Lin H, Cho JH, Park JH, Lee SD, Bae J, Kang KM, Kim YG, Pae
AN, Ko H, Park CS, Yoon MH, Kim YC. Discovery of Potent Antiallodynic Agents for
Neuropathic Pain Targeting P2X3 Receptors. ACS Chem Neurosci. 2017 Apr 6. doi:
10.1021/acschemneuro.6b00401. [Epub ahead of print] PubMed PMID: 28323403.