AC-7954

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531398

CAS#: 734528-95-1

Description: AC-7954 is a novel potent and efficacious nonpeptidic urotensin II receptor agonist.

Chemical Structure

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AC-7954
CAS# 734528-95-1
Instruction

Theoretical Analysis

MedKoo Cat#: 531398
Name: AC-7954
CAS#: 734528-95-1
Chemical Formula: C19H20ClNO2
Exact Mass: 329.12
Molecular Weight: 329.824
Elemental Analysis: C, 69.19; H, 6.11; Cl, 10.75; N, 4.25; O, 9.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AC-7954

IUPAC/Chemical Name: 3-(4-chlorophenyl)-3-(2-dimethylaminoethyl)isochroman-1-one

InChi Key: HIVBATDUVFEJFZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20ClNO2/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19/h3-10H,11-13H2,1-2H3

SMILES Code: O=C1OC(CCN(C)C)(C2=CC=C(Cl)C=C2)CC3=C1C=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 329.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Palabiyik SS, Karakus E, Akpinar E, Halici Z, Bayir Y, Yayla M, Kose D. The Role of Urotensin Receptors in the Paracetamol-Induced Hepatotoxicity Model in Mice: Ameliorative Potential of Urotensin II Antagonist. Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):150-9. doi: 10.1111/bcpt.12447. PubMed PMID: 26176337.

2: Lehmann F, Pettersen A, Currier EA, Sherbukhin V, Olsson R, Hacksell U, Luthman K. Novel potent and efficacious nonpeptidic urotensin II receptor agonists. J Med Chem. 2006 Apr 6;49(7):2232-40. PubMed PMID: 16570919.

3: Lehmann F, Currier EA, Olsson R, Hacksell U, Luthman K. Isochromanone-based urotensin-II receptor agonists. Bioorg Med Chem. 2005 Apr 15;13(8):3057-68. PubMed PMID: 15781415.

4: Mori M. [Development of therapeutic agents related to urotensin II]. Nihon Rinsho. 2004 Sep;62 Suppl 9:741-4. Review. Japanese. PubMed PMID: 15506486.

5: Carotenuto A, Grieco P, Campiglia P, Novellino E, Rovero P. Unraveling the active conformation of urotensin II. J Med Chem. 2004 Mar 25;47(7):1652-61. PubMed PMID: 15027856.

6: Croston GE, Olsson R, Currier EA, Burstein ES, Weiner D, Nash N, Severance D, Allenmark SG, Thunberg L, Ma JN, Mohell N, O'Dowd B, Brann MR, Hacksell U. Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954). J Med Chem. 2002 Nov 7;45(23):4950-3. PubMed PMID: 12408704.