AC55649
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531396

CAS#: 59662-49-6

Description: AC55649 is a retinoic acid receptor β2 agonist.

Chemical Structure

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AC55649
CAS# 59662-49-6
Instruction

Theoretical Analysis

MedKoo Cat#: 531396
Name: AC55649
CAS#: 59662-49-6
Chemical Formula: C21H26O2
Exact Mass: 310.19
Molecular Weight: 310.437
Elemental Analysis: C, 81.25; H, 8.44; O, 10.31

Price and Availability

Size Price Availability Quantity
50mg USD 250 2 Weeks
100mg USD 450 2 Weeks
200mg USD 750 2 Weeks
500mg USD 1450 2 Weeks
1g USD 2250 2 Weeks
2g USD 4250 2 Weeks
Bulk inquiry

Synonym: AC55649; AC-55649; AC 55649;

IUPAC/Chemical Name: 4-(4-octylphenyl)benzoic acid

InChi Key: HXBKPYIEQLLNBK-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H26O2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)19-13-15-20(16-14-19)21(22)23/h9-16H,2-8H2,1H3,(H,22,23)

SMILES Code: O=C(O)C1=CC=C(C2=CC=C(CCCCCCCC)C=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 310.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Trasino SE, Tang XH, Jessurun J, Gudas LJ. Retinoic acid receptor β2 agonists restore glycaemic control in diabetes and reduce steatosis. Diabetes Obes Metab. 2016 Feb;18(2):142-51. doi: 10.1111/dom.12590. PubMed PMID: 26462866; PubMed Central PMCID: PMC4948868.

2: Cuervo R, Chimal-Monroy J. Chemical activation of RARβ induces post-embryonically bilateral limb duplication during Xenopus limb regeneration. Sci Rep. 2013;3:1886. doi: 10.1038/srep01886. PubMed PMID: 23703360; PubMed Central PMCID: PMC3662968.

3: Lund BW, Knapp AE, Piu F, Gauthier NK, Begtrup M, Hacksell U, Olsson R. Design, synthesis, and structure-activity analysis of isoform-selective retinoic acid receptor beta ligands. J Med Chem. 2009 Mar 26;52(6):1540-5. doi: 10.1021/jm801532e. PubMed PMID: 19239230.

4: Lund BW, Piu F, Gauthier NK, Eeg A, Currier E, Sherbukhin V, Brann MR, Hacksell U, Olsson R. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9. PubMed PMID: 16302793.