WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530112
Description: ONO-1603 is a prolyl endopeptidase inhibitor potentially for the treatment of Alzheimer's disease.
MedKoo Cat#: 530112
Chemical Formula: C16H19ClN2O3
Exact Mass: 322.11
Molecular Weight: 322.79
Elemental Analysis: C, 59.54; H, 5.93; Cl, 10.98; N, 8.68; O, 14.87
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: ONO1603; ONO 1603; ONO-1603
IUPAC/Chemical Name: 1-Pyrrolidinebutanamide,N-[(4-chlorophenyl)methyl]-2-formyl-g-oxo-, (S)
InChi Key: KGDFDVHLEYUZLN-AWEZNQCLSA-N
InChi Code: InChI=1S/C16H19ClN2O3/c17-13-5-3-12(4-6-13)10-18-15(21)7-8-16(22)19-9-1-2-14(19)11-20/h3-6,11,14H,1-2,7-10H2,(H,18,21)/t14-/m0/s1
SMILES Code: O=C(NCC1=CC=C(Cl)C=C1)CCC(N2[C@H](C=O)CCC2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 322.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Katsube N, Sunaga K, Aishita H, Chuang DM, Ishitani R. ONO-1603, a potential antidementia drug, delays age-induced apoptosis and suppresses overexpression of glyceraldehyde-3-phosphate dehydrogenase in cultured central nervous system neurons. J Pharmacol Exp Ther. 1999 Jan;288(1):6-13. PubMed PMID: 9862746.
2: Katsube N, Sunaga K, Chuang DM, Ishitani R. ONO-1603, a potential antidementia drug, shows neuroprotective effects and increases m3-muscarinic receptor mRNA levels in differentiating rat cerebellar granule neurons. Neurosci Lett. 1996 Aug 23;214(2-3):151-4. PubMed PMID: 8878106.