WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531379

CAS#: 161395-35-3

Description: ABT-299 is a prodrug of A-85783.

Price and Availability




ABT-299 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 531379
Name: ABT-299
CAS#: 161395-35-3
Chemical Formula: C32H28ClFN4O4S
Exact Mass: 618.1504
Molecular Weight: 619.1084
Elemental Analysis: C, 62.08; H, 4.56; Cl, 5.73; F, 3.07; N, 9.05; O, 10.34; S, 5.18

Synonym: ABT-299

IUPAC/Chemical Name: [3-[(3R)-7-[1-(dimethylcarbamoyl)-6-(4-fluorophenyl)indole-3-carbonyl]-1,3-dihydropyrrolo[1,2-c][1,3]thiazol-3-yl]pyridin-1-ium-1-yl]methyl acetate chloride


InChi Code: InChI=1S/C32H28FN4O4S.ClH/c1-20(38)41-19-35-13-4-5-23(16-35)31-36-14-12-26(29(36)18-42-31)30(39)27-17-37(32(40)34(2)3)28-15-22(8-11-25(27)28)21-6-9-24(33)10-7-21;/h4-17,31H,18-19H2,1-3H3;1H/q+1;/p-1/t31-;/m1./s1

SMILES Code: CC(OC[N+]1=CC=CC([C@H]2SCC3=C(C(C4=CN(C(N(C)C)=O)C5=C4C=CC(C6=CC=C(F)C=C6)=C5)=O)C=CN23)=C1)=O.[Cl-]

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:


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4: Albert DH, Magoc TJ, Menacherry SD, Morgan DW, Sun E, Reyes AE, Kleinert HD, Carter GW, Summers JB. Ex vivo inhibition of beta-thromboglobulin release following administration to man of ABT-299, a novel prodrug of a potent platelet activating factor antagonist. Inflamm Res. 1997 Jul;46(7):272-7. PubMed PMID: 9266276.

5: Albert DH, Luo G, Magoc TJ, Tapang P, Holms JH, Davidsen SK, Summers JB, Carter GW. ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. Shock. 1996 Aug;6(2):112-7. PubMed PMID: 8856845.

6: Albert DH, Conway RG, Magoc TJ, Tapang P, Rhein DA, Luo G, Holms JH, Davidsen SK, Summers JB, Carter GW. Properties of ABT-299, a prodrug of A-85783, a highly potent platelet activating factor receptor antagonist. J Pharmacol Exp Ther. 1996 Jun;277(3):1595-606. PubMed PMID: 8667228.

7: Kruse-Elliott KT, Albert DH, Summers JB, Carter GW, Zimmerman JJ, Grossman JE. Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. Shock. 1996 Apr;5(4):265-73. PubMed PMID: 8721386.

8: Albert DH, Magoc TJ, Kleinert HD, Sun E, Reyes AE, Carter GW, Summers JB. Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. Adv Exp Med Biol. 1996;416:381-7. PubMed PMID: 9131177.

9: Summers JB, Albert DH, Davidsen SK, Conway RG, Holms JH, Magoc TJ, Luo G, Tapang P, Rhein DA, Carter GW. ABT-299, a potent antagonist of platelet activating factor. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:475-7. PubMed PMID: 7732895.

10: Davidsen SK, Summers JB, Albert DH, Holms JH, Heyman HR, Magoc TJ, Conway RG, Rhein DA, Carter GW. N-(acyloxyalkyl)pyridinium salts as soluble prodrugs of a potent platelet activating factor antagonist. J Med Chem. 1994 Dec 23;37(26):4423-9. PubMed PMID: 7799395.