WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 530441
CAS#: 152273-12-6
Description: U-93631 is a GABAA receptor antagonist. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.
MedKoo Cat#: 530441
Name: U-93631
CAS#: 152273-12-6
Chemical Formula: C17H21N3O2
Exact Mass: 299.1634
Molecular Weight: 299.374
Elemental Analysis: C, 68.20; H, 7.07; N, 14.04; O, 10.69
Synonym: U93631, U-93631, U 93631
IUPAC/Chemical Name: 4,5-Dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid 1,1-dimethylethyl ester
InChi Key: NXBSEJKZKXIYMD-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H21N3O2/c1-16(2,3)22-15(21)13-14-17(4,5)19-11-8-6-7-9-12(11)20(14)10-18-13/h6-10,19H,1-5H3
SMILES Code: O=C(C1=C2N(C=N1)C3=C(C=CC=C3)NC2(C)C)OC(C)(C)C
1: Dillon GH, Im HK, Hamilton BJ, Carter DB, Gammill RB, Judge TM, Im WB. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors. Mol Pharmacol. 1993 Oct;44(4):860-5. PubMed PMID: 8232235.
2: Bell-Horner CL, Dibas M, Huang RQ, Drewe JA, Dillon GH. Influence of subunit configuration on the interaction of picrotoxin-site ligands with recombinant GABA(A) receptors. Brain Res Mol Brain Res. 2000 Mar 10;76(1):47-55. PubMed PMID: 10719214.
3: Das P, Bell-Horner CL, Machu TK, Dillon GH. The GABA(A) receptor antagonist picrotoxin inhibits 5-hydroxytryptamine type 3A receptors. Neuropharmacology. 2003 Mar;44(4):431-8. PubMed PMID: 12646280.
4: Dillon GH, Im WB, Pregenzer JF, Carter DB, Hamilton BJ. [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability. J Pharmacol Exp Ther. 1995 Feb;272(2):597-603. PubMed PMID: 7531762.
5: Dillon GH, Im WB, Carter DB, McKinley DD. Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned alpha 1 beta 2 gamma 2 GABAA receptor subtype. Br J Pharmacol. 1995 Jun;115(3):539-45. PubMed PMID: 7582470; PubMed Central PMCID: PMC1908408.