Lys05 trihydrochloride
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MedKoo CAT#: 406969

CAS#: 1391426-24-6

Description: Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 150 Same day
25mg USD 250 Same day
50mg USD 450 Same day
100mg USD 650 Same day
200mg USD 950 Same day
500mg USD 1650 Same day
1g USD 2950 Same day
2g USD 4650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

Lys05 trihydrochloride, purity > 98%, is in stock.The same day shipping after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406969
Name: Lys05 trihydrochloride
CAS#: 1391426-24-6
Chemical Formula: C23H26Cl5N5
Exact Mass: 439.1331
Molecular Weight: 549.75
Elemental Analysis: C, 50.25; H, 4.77; Cl, 32.24; N, 12.74


Related CAS #: 1391426-24-6 (HCl)   1391426-22-4 (free/Lys01)  

Synonym: LYS-05 HCl; LYS05; LYS-05; Lys01 (trihydrochloride); Lys01 HCl salt.

IUPAC/Chemical Name: N2-(7-Chloro-4-quinolinyl)-N1-[2-[(7-chloro-4-quinolinyl)amino]ethyl]-N1-methyl-1,2-ethanediamine trihydrochloride

InChi Key: JTUYDBHQGOZPQQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H23Cl2N5.3ClH/c1-30(12-10-28-20-6-8-26-22-14-16(24)2-4-18(20)22)13-11-29-21-7-9-27-23-15-17(25)3-5-19(21)23;;;/h2-9,14-15H,10-13H2,1H3,(H,26,28)(H,27,29);3*1H

SMILES Code: CN(CCNC1=CC=NC2=CC(Cl)=CC=C12)CCNC3=CC=NC4=CC(Cl)=CC=C34.[H]Cl.[H]Cl.[H]Cl


Technical Data

Appearance:
Brown solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO and water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Amaravadi RK, Winkler JD. Lys05: a new lysosomal autophagy inhibitor.
Autophagy. 2012 Sep;8(9):1383-4. doi: 10.4161/auto.20958. PubMed PMID: 22878685;
PubMed Central PMCID: PMC3442884.

2: McAfee Q, Zhang Z, Samanta A, Levi SM, Ma XH, Piao S, Lynch JP, Uehara T,
Sepulveda AR, Davis LE, Winkler JD, Amaravadi RK. Autophagy inhibitor Lys05 has
single-agent antitumor activity and reproduces the phenotype of a genetic
autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8. doi:
10.1073/pnas.1118193109. PubMed PMID: 22566612; PubMed Central PMCID: PMC3361415.

3: DeVorkin L, Hattersley M, Kim P, Ries J, Spowart J, Anglesio MS, Levi SM,
Huntsman DG, Amaravadi RK, Winkler JD, Tinker AV, Lum JJ. Autophagy Inhibition
Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma. Mol Cancer Res. 2016
Dec 7. pii: molcanres.0132.2016. [Epub ahead of print] PubMed PMID: 27927774.

4: Shi TT, Yu XX, Yan LJ, Xiao HT. Research progress of hydroxychloroquine and
autophagy inhibitors on cancer. Cancer Chemother Pharmacol. 2016 Nov 26. [Epub
ahead of print] Review. PubMed PMID: 27889812.