A61603

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531359

CAS#: 750531-54-5

Description: A61603 is an alpha-1A adrenergic receptor.


Chemical Structure

img
A61603
CAS# 750531-54-5

Theoretical Analysis

MedKoo Cat#: 531359
Name: A61603
CAS#: 750531-54-5
Chemical Formula: C14H19N3O3S
Exact Mass: 309.1147
Molecular Weight: 309.384
Elemental Analysis: C, 54.35; H, 6.19; N, 13.58; O, 15.51; S, 10.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 107756-30-9 (HBr)   750531-54-5 (free base)  

Synonym: A61603

IUPAC/Chemical Name: N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide

InChi Key: OQFCXJDXHCDLHX-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)

SMILES Code: CS(=O)(NC1=C2CCCC(C3=NCCN3)C2=CC=C1O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 309.384 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Skelly MJ, Ariwodola OJ, Weiner JL. Fear conditioning selectively disrupts noradrenergic facilitation of GABAergic inhibition in the basolateral amygdala. Neuropharmacology. 2017 Feb;113(Pt A):231-240. doi: 10.1016/j.neuropharm.2016.10.003. PubMed PMID: 27720769; PubMed Central PMCID: PMC5148638.

2: Thomas RC, Singh A, Cowley P, Myagmar BE, Montgomery MD, Swigart PM, De Marco T, Baker AJ, Simpson PC. A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci. 2016 Apr;1(3):155-167. PubMed PMID: 27453955; PubMed Central PMCID: PMC4955869.

3: Thomas RC Jr, Cowley PM, Singh A, Myagmar BE, Swigart PM, Baker AJ, Simpson PC. The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PLoS One. 2016 Jun 3;11(6):e0155238. doi: 10.1371/journal.pone.0155238. PubMed PMID: 27258143; PubMed Central PMCID: PMC4892533.

4: Ge D, Yan X, Guo Y, Chen X, Guan R, Chen Y, Qiu D, Wang J. Activation of α1-adrenoceptors facilitates excitatory inputs to medullary airway vagal preganglionic neurons. J Appl Physiol (1985). 2015 Sep 15;119(6):686-95. doi: 10.1152/japplphysiol.00045.2015. PubMed PMID: 26205539.

5: Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ. The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H888-96. doi: 10.1152/ajpheart.00042.2015. PubMed PMID: 26116709; PubMed Central PMCID: PMC4591405.

6: Davis BJ, Wiener M, Chapple CR, Sellers DJ, Chess-Williams R. Functional and radioligand binding characterization of the α1L-adrenoceptor subtype of the human vas deferens. Auton Autacoid Pharmacol. 2015 Apr;34(3-4):41-9. doi: 10.1111/aap.12023. PubMed PMID: 25790239.

7: Ennis RC, Asico LD, Armando I, Yang J, Feranil JB, Jurgens JA, Escano CS Jr, Yu P, Wang X, Sibley DR, Jose PA, Villar VA. Dopamine D₁-like receptors regulate the α₁A-adrenergic receptor in human renal proximal tubule cells and D₁-like dopamine receptor knockout mice. Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1238-48. doi: 10.1152/ajprenal.00119.2014. PubMed PMID: 25339698; PubMed Central PMCID: PMC4254972.

8: Yoshiki H, Uwada J, Umada H, Kobayashi T, Takahashi T, Yamakawa T, Yamaguchi A, Yokoyama O, Muramatsu I. Agonist pharmacology at recombinant α1A - and α1L -adrenoceptors and in lower urinary tract α1 -adrenoceptors. Br J Pharmacol. 2013 Nov;170(6):1242-52. doi: 10.1111/bph.12403. PubMed PMID: 24024968; PubMed Central PMCID: PMC3838699.

9: Amirak E, Fuller SJ, Sugden PH, Clerk A. p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. Biochem J. 2013 Mar 1;450(2):351-63. doi: 10.1042/BJ20121371. PubMed PMID: 23215897; PubMed Central PMCID: PMC3573779.

10: Moro C, Tajouri L, Chess-Williams R. Adrenoceptor function and expression in bladder urothelium and lamina propria. Urology. 2013 Jan;81(1):211.e1-7. doi: 10.1016/j.urology.2012.09.011. PubMed PMID: 23200975.

11: Martínez-Salas SG, Campos-Peralta JM, Pardo JP, Hernández-Muñoz R, Ibarra M, Tanoue A, Tsujimoto G, Villalobos-Molina R. α(1D)-Adrenoceptor regulates the vasopressor action of α(1A)-adrenoceptor in mesenteric vascular bed of α(1D)-adrenoceptor knockout mice. Auton Autacoid Pharmacol. 2011 Jul-Oct;31(3-4):64-71. doi: 10.1111/j.1474-8673.2011.00468.x. PubMed PMID: 21951586.

12: Rank MM, Murray KC, Stephens MJ, D'Amico J, Gorassini MA, Bennett DJ. Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury. J Neurophysiol. 2011 Jan;105(1):410-22. doi: 10.1152/jn.00775.2010. PubMed PMID: 21047936; PubMed Central PMCID: PMC3023364.

13: Evans BA, Broxton N, Merlin J, Sato M, Hutchinson DS, Christopoulos A, Summers RJ. Quantification of functional selectivity at the human α(1A)-adrenoceptor. Mol Pharmacol. 2011 Feb;79(2):298-307. doi: 10.1124/mol.110.067454. Erratum in: Mol Pharmacol. 2011 Mar;79(3):627. PubMed PMID: 20978120.

14: Copik AJ, Ma C, Kosaka A, Sahdeo S, Trane A, Ho H, Dietrich PS, Yu H, Ford AP, Button D, Milla ME. Facilitatory interplay in alpha 1a and beta 2 adrenoceptor function reveals a non-Gq signaling mode: implications for diversification of intracellular signal transduction. Mol Pharmacol. 2009 Mar;75(3):713-28. doi: 10.1124/mol.108.050765. PubMed PMID: 19109357.

15: Mills K, Hausman N, Chess-Williams R. Characterization of the alpha1-adrenoceptor subtype mediating contractions of the pig internal anal sphincter. Br J Pharmacol. 2008 Sep;155(1):110-7. doi: 10.1038/bjp.2008.217. PubMed PMID: 18516067; PubMed Central PMCID: PMC2527848.

16: O-Uchi J, Sasaki H, Morimoto S, Kusakari Y, Shinji H, Obata T, Hongo K, Komukai K, Kurihara S. Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ Res. 2008 Jun 6;102(11):1378-88. doi: 10.1161/CIRCRESAHA.107.167734. PubMed PMID: 18467629.

17: Rojas Gomez DM, Schulte JS, Mohr FW, Dhein S. Alpha-1-adrenoceptor subtype selective regulation of connexin 43 expression in rat cardiomyocytes. Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):77-85. doi: 10.1007/s00210-007-0244-9. PubMed PMID: 18193202.

18: Luo DL, Gao J, Fan LL, Tang Y, Zhang YY, Han QD. Receptor subtype involved in alpha 1-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta Pharmacol Sin. 2007 Jul;28(7):968-74. PubMed PMID: 17588332.

19: Martínez-Salas SG, Campos-Peralta JM, Pares-Hipolito J, Gallardo-Ortíz IA, Ibarra M, Villalobos-Molina R. Alpha1A-adrenoceptors predominate in the control of blood pressure in mouse mesenteric vascular bed. Auton Autacoid Pharmacol. 2007 Jul;27(3):137-42. PubMed PMID: 17584443.

20: Mehrotra S, Gupta S, Centurión D, Villalón CM, Saxena PR, VandenBrink AM. A61603-induced contractions of the porcine meningeal artery are mediated by alpha1- and alpha2-adrenoceptors. Basic Clin Pharmacol Toxicol. 2007 Apr;100(4):279-85. PubMed PMID: 17371533.