WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 531342
Description: A-119637 is a novel, selective and potent alpha1D antagonist.
MedKoo Cat#: 531342
Chemical Formula: C25H26N4O3S
Exact Mass: 462.1726
Molecular Weight: 462.568
Elemental Analysis: C, 64.91; H, 5.67; N, 12.11; O, 10.38; S, 6.93
This product is not in stock, which may be available by custom synthesis.
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IUPAC/Chemical Name: 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-5-phenyl-1H-thieno[3,2-e]pyrimidine-2,4-dione
InChi Key: HLVQBOYEHQRWHG-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H26N4O3S/c1-32-21-10-6-5-9-20(21)28-14-11-27(12-15-28)13-16-29-24(30)22-19(18-7-3-2-4-8-18)17-33-23(22)26-25(29)31/h2-10,17H,11-16H2,1H3,(H,26,31)
SMILES Code: O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C(C4=CC=CC=C4)=CS5)=C5N1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 462.568 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Mizusawa H, Hedlund P, Sjunnesson J, Brioni JD, Sullivan JP, Andersson KE. Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist. Br J Pharmacol. 2002 Jul;136(5):701-8. PubMed PMID: 12086979; PubMed Central PMCID: PMC1573401.
2: Carroll WA, Sippy KB, Esbenshade TA, Buckner SA, Hancock AA, Meyer MD. Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien. Bioorg Med Chem Lett. 2001 May 7;11(9):1119-21. PubMed PMID: 11354357.