WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531253

CAS#: 1435467-38-1

Description: PF-06281355, also known as PF-1355, is an orally available, selective and potent mechanism based inhibitor of the myeloperoxidase (MPO) that reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. PF-06281355 suppresses albuminuria and chronic renal dysfunction in model of anti-Glomerular Basement Membrane (GBM) disease. PF-1355 prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.

Price and Availability

Size Price Shipping out time Quantity
100mg USD 650 2 Weeks
200mg USD 950 2 Weeks
500mg USD 1650 2 Weeks
1g USD 2650 2 Weeks
2g USD 3950 2 Weeks
5g USD 5850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-24. Prices are subject to change without notice.

PF-06281355, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 531253
Name: PF-06281355
CAS#: 1435467-38-1
Chemical Formula: C14H15N3O4S
Exact Mass: 321.0783
Molecular Weight: 321.351
Elemental Analysis: C, 52.33; H, 4.71; N, 13.08; O, 19.91; S, 9.98

Synonym: PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355.

IUPAC/Chemical Name: 2-(6-(2,5-Dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide


InChi Code: InChI=1S/C14H15N3O4S/c1-20-8-3-4-11(21-2)9(5-8)10-6-13(19)16-14(22)17(10)7-12(15)18/h3-6H,7H2,1-2H3,(H2,15,18)(H,16,19,22)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Zheng W, Warner R, Ruggeri R, Su C, Cortes C, Skoura A, Ward J, Ahn K,
Kalgutkar A, Sun D, Maurer TS, Bonin PD, Okerberg C, Bobrowski W, Kawabe T, Zhang
Y, Coskran T, Bell S, Kapoor B, Johnson K, Buckbinder L. PF-1355, a
mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and
anti-glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther. 2015
May;353(2):288-98. doi: 10.1124/jpet.114.221788. PubMed PMID: 25698787.