WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 531253
CAS#: 1435467-38-1
Description: PF-06281355, also known as PF-1355, is an orally available, selective and potent mechanism based inhibitor of the myeloperoxidase (MPO) that reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. PF-06281355 suppresses albuminuria and chronic renal dysfunction in model of anti-Glomerular Basement Membrane (GBM) disease. PF-1355 prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.
MedKoo Cat#: 531253
Name: PF-06281355
CAS#: 1435467-38-1
Chemical Formula: C14H15N3O4S
Exact Mass: 321.0783
Molecular Weight: 321.351
Elemental Analysis: C, 52.33; H, 4.71; N, 13.08; O, 19.91; S, 9.98
Synonym: PF-06281355; PF 06281355; PF06281355; PF-1355; PF 1355; PF1355.
IUPAC/Chemical Name: 2-(6-(2,5-Dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide
InChi Key: LJBUZOGABRDGBR-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H15N3O4S/c1-20-8-3-4-11(21-2)9(5-8)10-6-13(19)16-14(22)17(10)7-12(15)18/h3-6H,7H2,1-2H3,(H2,15,18)(H,16,19,22)
SMILES Code: O=C(N)CN(C(N1)=S)C(C2=CC(OC)=CC=C2OC)=CC1=O
1: Zheng W, Warner R, Ruggeri R, Su C, Cortes C, Skoura A, Ward J, Ahn K,
Kalgutkar A, Sun D, Maurer TS, Bonin PD, Okerberg C, Bobrowski W, Kawabe T, Zhang
Y, Coskran T, Bell S, Kapoor B, Johnson K, Buckbinder L. PF-1355, a
mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and
anti-glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther. 2015
May;353(2):288-98. doi: 10.1124/jpet.114.221788. PubMed PMID: 25698787.