WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530205

CAS#: 135306-39-7 (free base)

Description: Manifaxine is a norepinephrine-dopamine reuptake inhibitor potentially for the treatment of attention deficit.

Price and Availability




Manifaxine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 530205
Name: Manifaxine
CAS#: 135306-39-7 (free base)
Chemical Formula: C12H15F2NO2
Exact Mass: 243.1071
Molecular Weight: 243.2538
Elemental Analysis: C, 59.25; H, 6.22; F, 15.62; N, 5.76; O, 13.15

Synonym: BW-1555U-88; GW-320659; 1555U-88; BW1555U88; GW320659; 1555U88; BW 1555U 88; GW 320659; 1555U 88

IUPAC/Chemical Name: (2S,3S,5R)-2-(3,5-Difluorophenyl)-3,5-dimethylmorpholin-2-ol


InChi Code: InChI=1S/C12H15F2NO2/c1-7-6-17-12(16,8(2)15-7)9-3-10(13)5-11(14)4-9/h3-5,7-8,15-16H,6H2,1-2H3/t7-,8+,12-/m1/s1

SMILES Code: O[C@]1(C2=CC(F)=CC(F)=C2)[C@H](C)N[C@H](C)CO1

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information

Related CAS No.
135306-39-7 (Manifaxine)
135306-42-2 (Manifaxine hydrochloride)


1: Spraggs CF, Pillai SG, Dow D, Douglas C, McCarthy L, Manasco PK, Stubbins M, Roses AD. Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects. Pharmacogenet Genomics. 2005 Dec;15(12):883-9. PubMed PMID: 16272960.

2: DeVeaugh-Geiss J, Conners CK, Sarkis EH, Winner PK, Ginsberg LD, Hemphill JM, Laurenza A, Barrows CE, Webster CJ, Stotka CJ, Asgharnejad M. GW320659 for the treatment of attention-deficit/hyperactivity disorder in children. J Am Acad Child Adolesc Psychiatry. 2002 Aug;41(8):914-20. PubMed PMID: 12162627.