WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 531198
Description: LH846 is a selective inhibitor of casein kinase. IC50 values of LH846 are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α). LH 846 has been shown to inhibit CK1δ-dependent phosphorylation and degradation of PER1 protein and to lengthen the circadian period in U2OS cells.
MedKoo Cat#: 531198
Chemical Formula: C16H13ClN2OS
Exact Mass: 316.0437
Molecular Weight: 316.803
Elemental Analysis: C, 60.66; H, 4.14; Cl, 11.19; N, 8.84; O, 5.05; S, 10.12
Synonym: LH846; LH-846; LH 846.
IUPAC/Chemical Name: N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
InChi Key: DYHAMRNAHTWYKY-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H13ClN2OS/c1-10-7-14-13(9-12(10)17)18-16(21-14)19-15(20)8-11-5-3-2-4-6-11/h2-7,9H,8H2,1H3,(H,18,19,20)
SMILES Code: O=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3
Unlike the great majority of protein kinases, which are tightly regulated enzymes, CK2 is endowed with high constitutive activity, a feature that is suspected to underlie its oncogenic potential and possible implication in viral infections. This makes CK2 an attractive target for anti-neoplastic and antiviral drugs.
1: Lee JW, Hirota T, Peters EC, Garcia M, Gonzalez R, Cho CY, Wu X, Schultz PG,
Kay SA. A small molecule modulates circadian rhythms through phosphorylation of
the period protein. Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11. doi:
10.1002/anie.201103915. PubMed PMID: 21954091; PubMed Central PMCID: PMC3755734.