Ilaprazole
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 531183

CAS#: 172152-36-2

Description: Ilaprazole, also known as IY81149 is an Anti-ulcer agent. Ilaprazole is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Clinical studies show that ilaprazole is at least as potent a PPI as omeprazole when taken in equivalent doses. Studies also showed that ilaprazole significantly prevented the development of reflux oesophagitis.


Chemical Structure

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Ilaprazole
CAS# 172152-36-2

Theoretical Analysis

MedKoo Cat#: 531183
Name: Ilaprazole
CAS#: 172152-36-2
Chemical Formula: C19H18N4O2S
Exact Mass: 366.115
Molecular Weight: 366.439
Elemental Analysis: C, 62.28; H, 4.95; N, 15.29; O, 8.73; S, 8.75

Price and Availability

Size Price Availability Quantity
5.0mg USD 275.0 2 Weeks
25.0mg USD 750.0 2 Weeks
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Synonym: Ilaprazole; IY81149; IY-81149; IY 81149; trade name Noltec.

IUPAC/Chemical Name: 1H-Benzimidazole,2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-5-(1H-pyrrol-1-yl)- (9CI)

InChi Key: HRRXCXABAPSOCP-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18N4O2S/c1-13-17(20-8-7-18(13)25-2)12-26(24)19-21-15-6-5-14(11-16(15)22-19)23-9-3-4-10-23/h3-11H,12H2,1-2H3,(H,21,22)

SMILES Code: O=S(C1=NC2=CC(N3C=CC=C3)=CC=C2N1)CC4=NC=CC(OC)=C4C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 366.439 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhou G, Shi S, Zhang W, Tan Z, Chen Y, Guo D, Zhou H, Hu H, Tan J. Identification of ilaprazole metabolites in human urine by HPLC-ESI-MS/MS and HPLC-NMR experiments. Biomed Chromatogr. 2010 Oct;24(10):1130-5. doi: 10.1002/bmc.1416. PubMed PMID: 20352613.

2: Scarpignato C, Pelosini I, Di Mario F. Acid suppression therapy: where do we go from here? Dig Dis. 2006;24(1-2):11-46. Review. PubMed PMID: 16699262.