WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 329469
CAS#: 65-23-6 (free base)
Description: Pyridoxine (also called pyridoxol, not to be confused with pyridoxal) is one form of vitamin B6. Its hydrochloride salt, pyridoxine hydrochloride, is used as a vitamin B6 dietary supplement.
MedKoo Cat#: 329469
Name: Pyridoxine free base
CAS#: 65-23-6 (free base)
Chemical Formula: C8H11NO3
Exact Mass: 69.0739
Molecular Weight: 169.18
Elemental Analysis: C, 56.80; H, 6.55; N, 8.28; O, 28.37
Related CAS #: 65-23-6 (free base) 58-56-0 (hydrochloride)
Synonym: Pyridoxine; pyridoxol. vitamin B6.
IUPAC/Chemical Name: 4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol
InChi Key: LXNHXLLTXMVWPM-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
SMILES Code: OC1=C(CO)C(CO)=CN=C1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 169.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: van Karnebeek CD, Tiebout SA, Niermeijer J, Poll-The BT, Ghani A, Coughlin CR 2nd, Van Hove JL, Richter JW, Christen HJ, Gallagher R, Hartmann H, Stockler-Ipsiroglu S. Pyridoxine-Dependent Epilepsy: An Expanding Clinical Spectrum. Pediatr Neurol. 2016 Jun;59:6-12. doi: 10.1016/j.pediatrneurol.2015.12.013. Review. PubMed PMID: 26995068.
2: Dakshinamurti S, Dakshinamurti K. Antihypertensive and neuroprotective actions of pyridoxine and its derivatives. Can J Physiol Pharmacol. 2015 Dec;93(12):1083-90. doi: 10.1139/cjpp-2015-0098. Review. PubMed PMID: 26281007.
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4: Coughlin CR 2nd, van Karnebeek CD, Al-Hertani W, Shuen AY, Jaggumantri S, Jack RM, Gaughan S, Burns C, Mirsky DM, Gallagher RC, Van Hove JL. Triple therapy with pyridoxine, arginine supplementation and dietary lysine restriction in pyridoxine-dependent epilepsy: Neurodevelopmental outcome. Mol Genet Metab. 2015 Sep-Oct;116(1-2):35-43. doi: 10.1016/j.ymgme.2015.05.011. Review. PubMed PMID: 26026794.
5: Jo SJ, Shin H, Jo S, Kwon O, Myung SK. Prophylactic and therapeutic efficacy of pyridoxine supplements in the management of hand-foot syndrome during chemotherapy: a meta-analysis. Clin Exp Dermatol. 2015 Apr;40(3):260-70. doi: 10.1111/ced.12538. Review. PubMed PMID: 25557587.
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10: Yang ZX, Qin J. [Advances in clinical and molecular genetic research on pyridoxine dependent epilepsy]. Zhonghua Er Ke Za Zhi. 2013 Nov;51(11):867-70. Review. Chinese. PubMed PMID: 24484566.
11: Chen M, Zhang L, Wang Q, Shen J. Pyridoxine for prevention of hand-foot syndrome caused by chemotherapy: a systematic review. PLoS One. 2013 Aug 20;8(8):e72245. doi: 10.1371/journal.pone.0072245. Review. PubMed PMID: 23977264; PubMed Central PMCID: PMC3748123.
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13: Stockler S, Plecko B, Gospe SM Jr, Coulter-Mackie M, Connolly M, van Karnebeek C, Mercimek-Mahmutoglu S, Hartmann H, Scharer G, Struijs E, Tein I, Jakobs C, Clayton P, Van Hove JL. Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up. Mol Genet Metab. 2011 Sep-Oct;104(1-2):48-60. doi: 10.1016/j.ymgme.2011.05.014. Review. PubMed PMID: 21704546.
14: Bowling FG. Pyridoxine supply in human development. Semin Cell Dev Biol. 2011 Aug;22(6):611-8. doi: 10.1016/j.semcdb.2011.05.003. Review. PubMed PMID: 21664474.
15: van der Watt JJ, Harrison TB, Benatar M, Heckmann JM. Polyneuropathy, anti-tuberculosis treatment and the role of pyridoxine in the HIV/AIDS era: a systematic review. Int J Tuberc Lung Dis. 2011 Jun;15(6):722-8. doi: 10.5588/ijtld.10.0284. Review. PubMed PMID: 21477422.
16: Torshin IIu, Gromova OA, Gusev EI. [Mechanisms of antistress and antidepressive effects of magnesium and pyridoxine]. Zh Nevrol Psikhiatr Im S S Korsakova. 2009;109(11):107-11. Review. Russian. PubMed PMID: 20120072.
17: Thaver D, Saeed MA, Bhutta ZA. Pyridoxine (vitamin B6) supplementation in pregnancy. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD000179. Review. Update in: Cochrane Database Syst Rev. 2015;6:CD000179. PubMed PMID: 16625530.
18: Gospe SM Jr. Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. Curr Opin Neurol. 2006 Apr;19(2):148-53. Review. PubMed PMID: 16538088.
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Related CAS#
CAS#65-23-6 (Pyridoxine free base)
CAS#58-56-0 (Pyridoxine hydrochloride)
