Eclanamine maleate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329468

CAS#: 67450-45-7 (maleate)

Description: Eclanamine, also known as U-48753E, is a potential agent which was subjected to a battery of short-term assays for genetic activity. U-48753E was discovered to be slightly mutagenic in the AS52 assay, and significant efforts were expended in evaluation of the metabolism-based generation of a reactive intermediate.

Price and Availability




Eclanamine maleate is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 329468
Name: Eclanamine maleate
CAS#: 67450-45-7 (maleate)
Chemical Formula: C20H26Cl2N2O5
Exact Mass:
Molecular Weight: 445.337
Elemental Analysis: C, 53.94; H, 5.88; Cl, 15.92; N, 6.29; O, 17.96

Synonym: Eclanamine maleate; U-48,753E; U48,753E; U 48,753E; U-48753E; U48753E; U 48753E.

IUPAC/Chemical Name: N-(3,4-dichlorophenyl)-N-[(1R,2R)-2-(dimethylamino)cyclopentyl]-propanamide maleate


InChi Code: InChI=1S/C16H22Cl2N2O.C4H4O4/c1-4-16(21)20(11-8-9-12(17)13(18)10-11)15-7-5-6-14(15)19(2)3;5-3(6)1-2-4(7)8/h8-10,14-15H,4-7H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15-;/m1./s1

SMILES Code: CCC(N(C1=CC=C(Cl)C(Cl)=C1)[C@H]2[C@H](N(C)C)CCC2)=O.O=C(O)/C=C\C(O)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information

Related CAS#
CAS#67450-45-7 (Eclanamine maleate)
CAS#67450-44-6 (Eclanamine free base)


1: Aaron CS, Harbach PR, Mattano SS, Mayo JK, Wang Y, Yu RL, Zimmer DM. Risk and
benefit evaluation in development of pharmaceutical products. Environ Health
Perspect. 1993 Oct;101 Suppl 3:291-5. Review. PubMed PMID: 8143634; PubMed
Central PMCID: PMC1521120.

2: Aaron CS, Stankowski LF Jr, Harbach PR, Valencia R, Mayo JK, Mirsalis J,
Mazurek JH, Steinmetz KL, Wiser SK, Zimmer DM, et al. Comparative mutagenicity
testing of a drug candidate, U-48753E: mechanism of induction of gene mutations
in mammalian cells and quantitation of potential hazard. Mutat Res. 1989
Jun;223(2):111-20. PubMed PMID: 2500592.

3: Sethy VH, Day JS, Cooper MM. Dose-dependent down-regulation of beta-adrenergic
receptors after chronic intravenous infusion of antidepressants. Prog
Neuropsychopharmacol Biol Psychiatry. 1988;12(5):673-82. PubMed PMID: 2851860.