Tubastatin A HCl
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MedKoo CAT#: 407429

CAS#: 1310693-92-5 (HCl)

Description: Tubastatin A is a potent and selective HDAC6 inhibitor. Tubastatin A demonstrates 1093-fold selectivity over HDAC1 (IC50 values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50 >16 μM), excluding HDAC8 (IC50= 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 190 2 weeks
100mg USD 350 2 weeks
200mg USD 650 2 weeks
500mg USD 1450 2 weeks
1g USD 2350 2 weeks
2g USD 4450 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-20. Prices are subject to change without notice.

Tubastatin A HCl, purity > 98%, is in stock.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407429
Name: Tubastatin A HCl
CAS#: 1310693-92-5 (HCl)
Chemical Formula: C20H22ClN3O
Exact Mass:
Molecular Weight: 371.865
Elemental Analysis: C, 64.60; H, 5.96; Cl, 9.53; N, 11.30; O, 8.60


Related CAS #: 1310693-92-5 (HCl)   1252003-15-8 (free base)    

Synonym: Tubastatin A HCl; Tubastatin A hydrochloride.

IUPAC/Chemical Name: N-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide hydrochloride

InChi Key: LJTSJTWIMOGKRJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H

SMILES Code: O=C(NO)C1=CC=C(CN2C3=C(CN(C)CC3)C4=C2C=CC=C4)C=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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