SR-3029
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MedKoo CAT#: 406961

CAS#: 1454585-06-8

Description: SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with potent antiproliferative properties SR-3029 shoed IC50:= 97 nM in MTT assays against the human A375 melanoma cell line and have physical, in vitro and in vivo PK properties suitable for use in proof of principle animal xenograft studies against human cancer cell lines.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2450 2 Weeks
1g USD 3250 2 Weeks
2g USD 5250 2 Weeks
5g USD 8950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

SR-3029 purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406961
Name: SR-3029
CAS#: 1454585-06-8
Chemical Formula: C23H19F3N8O
Exact Mass: 480.1634
Molecular Weight: 480.4552
Elemental Analysis: C, 57.50; H, 3.99; F, 11.86; N, 23.32; O, 3.33


Synonym: SR-3029; SR 3029; SR3029.

IUPAC/Chemical Name: (6,7-Difluoro-1H-benzoimidazol-2-ylmethyl)-[9-(3-fluoro-phenyl)-2-morpholin-4-yl-9H-purin-6-yl]-amine

InChi Key: CEBMEQPREMCWOL-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H19F3N8O/c24-13-2-1-3-14(10-13)34-12-28-20-21(31-23(32-22(20)34)33-6-8-35-9-7-33)27-11-17-29-16-5-4-15(25)18(26)19(16)30-17/h1-5,10,12H,6-9,11H2,(H,29,30)(H,27,31,32)

SMILES Code: FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Rosenberg LH, Lafitte M, Quereda V, Grant W, Chen W, Bibian M, Noguchi Y,
Fallahi M, Yang C, Chang JC, Roush WR, Cleveland JL, Duckett DR. Therapeutic
targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec
16;7(318):318ra202. doi: 10.1126/scitranslmed.aac8773. PubMed PMID: 26676609;
PubMed Central PMCID: PMC4809734.

2: Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht
K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR.
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with
potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug
1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. PubMed PMID: 23787102; PubMed
Central PMCID: PMC3783656.