Cambendazole
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329465

CAS#: 26097-80-3

Description: Cambendazole is one of the most effective agents for the therapy of human strongyloidiasis.


Chemical Structure

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Cambendazole
CAS# 26097-80-3

Theoretical Analysis

MedKoo Cat#: 329465
Name: Cambendazole
CAS#: 26097-80-3
Chemical Formula: C14H14N4O2S
Exact Mass: 302.0837
Molecular Weight: 302.352
Elemental Analysis: C, 55.62; H, 4.67; N, 18.53; O, 10.58; S, 10.60

Price and Availability

Size Price Availability Quantity
10.0mg USD 550.0 2 Weeks
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Synonym: Cambendazole; Novazole; Noviben; Equiben.

IUPAC/Chemical Name: isopropyl (2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-yl)carbamate

InChi Key: QZWHWHNCPFEXLL-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)

SMILES Code: O=C(OC(C)C)NC1=CC=C2C(N=C(C3=CSC=N3)N2)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 302.352 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Andrade SR, Scarminio IS, Nery MM, de Oliveira AC. Comparison of multivariate calibration methods to determine simultaneously mebendazole-cambendazole and mebendazole-thiabendazole in pharmaceutical preparations by UV-visible spectrophotometry. J Pharm Biomed Anal. 2003 Nov 24;33(4):655-65. PubMed PMID: 14623591.

2: Lyons ET, Drudge JH, Tolliver SC, Swerczek TW, Stamper S, Granstrom DE. Control of cambendazole-resistant small strongyles (Population S) with oxibendazole in a pony band: an 8 year field test (1984-1992). Vet Parasitol. 1994 Apr;52(3-4):271-7. PubMed PMID: 8073610.

3: Sharma RK, Singh K, Saxena KK. Effect of cambendazole and haloxon on the carbohydrate metabolism of Ascaridia galli and Heterakis gallinae (Nematoda). Angew Parasitol. 1990 May;31(2):101-5. PubMed PMID: 2389827.

4: Grove DI, Northern C. The effects of thiabendazole, mebendazole and cambendazole in normal and immunosuppressed dogs infected with a human strain of Strongyloides stercoralis. Trans R Soc Trop Med Hyg. 1988;82(1):146-9. PubMed PMID: 3176142.

5: Karmańska K, Michalska Z, Slaska B, Mielczarek J. [Trial of the modification of immunopathological changes in the muscular phase of trichinosis I. The effect of cambendazole]. Wiad Parazytol. 1987;33(4-5):517-24. Polish. PubMed PMID: 3452944.

6: Dorny P, Berghen P, Vercruysse J. Morphological changes in Capillaria obsignata (Nematoda: Trichuridae) eggs after treatment with cambendazole. Parasitol Res. 1987;74(2):196-7. PubMed PMID: 3438301.

7: Grove DI, Northern C. Strongyloides ratti and S. stercoralis: effects of cambendazole, thiabendazole and mebendazole in vitro. Rev Inst Med Trop Sao Paulo. 1986 Mar-Apr;28(2):97-103. PubMed PMID: 3797953.

8: Drudge JH, Lyons ET, Tolliver SC, Swerczek TW. Use of oxibendazole for control of cambendazole-resistant small strongyles in a band of ponies: a six-year study. Am J Vet Res. 1985 Dec;46(12):2507-11. PubMed PMID: 4083584.

9: Bliss EL, Greiner EC. Efficacy of fenbendazole and cambendazole against Muellerius capillaris in dairy goats. Am J Vet Res. 1985 Sep;46(9):1923-5. PubMed PMID: 4051297.

10: McCracken RO, Garcia A, Nierste DM, Dock D. The effect of dosage regimen on the efficacy of cambendazole against Trichinella spiralis. Int J Parasitol. 1985 Jun;15(3):309-12. PubMed PMID: 4030205.

11: Kawalek JC, Rew RS, Heavner J. Glutathione-S-transferase, a possible drug-metabolizing enzyme, in Haemonchus contortus: comparative activity of a cambendazole-resistant and a susceptible strain. Int J Parasitol. 1984 Apr;14(2):173-5. PubMed PMID: 6735580.

12: Bicalho SA, Leão OJ, Pena Q Jr. Cambendazole in the treatment of human strongyloidiasis. Am J Trop Med Hyg. 1983 Sep;32(5):1181-3. PubMed PMID: 6625071.

13: McCracken RO, Taylor DD. Biochemical effects of thiabendazole and cambendazole on Hymenolepis diminuta (Cestoda) in vivo. J Parasitol. 1983 Apr;69(2):295-301. PubMed PMID: 6854471.

14: Drudge JH, Lyons ET, Swerczek TW, Tolliver SC. Cambendazole for strongyle control in a pony band: selection of a drug-resistant population of small strongyles and teratologic implications. Am J Vet Res. 1983 Jan;44(1):110-4. PubMed PMID: 6824213.

15: Barański MC, da Silva AF, Kotaka PI, Gomes NR, Giovannoni M, Telles JE. Treatment of human strongyloidiasis with cambendazole, a new anthelminthic. Double-blind study. Mater Med Pol. 1983 Jan-Jun;15(1-2):36-8. PubMed PMID: 6400164.

16: Mirck MH, van Meurs GK. [Effect of albendazole and cambendazole on the egg output of Strongylidae in horses]. Tijdschr Diergeneeskd. 1982 Oct 1;107(19):731-6. Dutch. PubMed PMID: 7147218.

17: Grove DI. Strongyloides ratti and S. stercoralis: the effects of thiabendazole, mebendazole, and cambendazole in infected mice. Am J Trop Med Hyg. 1982 May;31(3 Pt 1):469-76. PubMed PMID: 7081540.

18: Herlich H, Rew RS, Colglazier ML. Inheritance of cambendazole resistance in Haemonchus contortus. Am J Vet Res. 1981 Aug;42(8):1342-4. PubMed PMID: 7294466.

19: Supperer R, Kutzer E. [Tolerance of mebendazole, fenbendazole, thiabendazole, cambendazole and febantel in relation to egg-laying capacity, egg quality, fertility and hatch rate of quail (Coturnix coturnix japonica)]. Berl Munch Tierarztl Wochenschr. 1981 Jun 1;94(11-12):211-5. German. PubMed PMID: 6895027.

20: Evans WS, Hardy M, Novak M. A comparison of the effect of albendazole, cambendazole, and thiabendazole on the larval development of three hymenolepidid cestodes. J Parasitol. 1980 Dec;66(6):935-40. PubMed PMID: 7218116.