WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 206772
CAS#: 1397922-61-0 (maleate)
Description: Pyrotinib maleate is a salt of Pyrotinib. Pyrotinib also known as SHR-1258, is an orally bioavailable, dual kinase inhibitor of the epidermal growth factor receptor (EGFR or HER-1) and the human epidermal growth factor receptor 2 (ErbB2 or HER-2), with potential antineoplastic activity. Upon oral administration, pyrotinib binds to and inhibits both EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumor cells. EGFR and HER2 are receptor tyrosine kinases that are upregulated in various tumor cell types and play major roles in tumor cell proliferation and tumor vascularization.
MedKoo Cat#: 206772
Name: Pyrotinib maleate
CAS#: 1397922-61-0 (maleate)
Chemical Formula: C36H35ClN6O7
Molecular Weight: 699.161
Elemental Analysis: C, 61.84; H, 5.05; Cl, 5.07; N, 12.02; O, 16.02
This product is not in stock, which may be available by custom synthesis.
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Synonym: Pyrotinib maleate; Pyrotinib; SHR-1258; SHR1258; SHR 1258.
IUPAC/Chemical Name: (R,E)-N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1-methylpyrrolidin-2-yl)acrylamide maleate
InChi Key: ZUZJPRMSUMMELD-ZLWATVBPSA-N
InChi Code: InChI=1S/C32H31ClN6O3.C4H4O4/c1-3-41-30-17-27-25(16-28(30)38-31(40)12-10-24-8-6-14-39(24)2)32(21(18-34)19-36-27)37-22-9-11-29(26(33)15-22)42-20-23-7-4-5-13-35-23;5-3(6)1-2-4(7)8/h4-5,7,9-13,15-17,19,24H,3,6,8,14,20H2,1-2H3,(H,36,37)(H,38,40);1-2H,(H,5,6)(H,7,8)/b12-10+;2-1-/t24-;/m1./s1
SMILES Code: O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/[C@@H]5N(C)CCC5.O=C(O)/C=C\C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 699.161 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Zhu Y, Li L, Zhang G, Wan H, Yang C, Diao X, Chen X, Zhang L, Zhong D.
Metabolic characterization of pyrotinib in humans by ultra-performance liquid
chromatography/quadrupole time-of-flight mass spectrometry. J Chromatogr B Analyt
Technol Biomed Life Sci. 2016 Oct 15;1033-1034:117-27. doi:
10.1016/j.jchromb.2016.08.009. PubMed PMID: 27541626.
1269662-73-8 (Pyrotinib free base)
1397922-61-0 (Pyrotinib maleate)