GLL398
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MedKoo CAT#: 206771

CAS#: 2077980-83-5

Description: GLL398 is an Oral Selective Estrogen Receptor Downregulator. GLL398 strongly binds to ERα in a fluorescence resonance energy transfer binding assay (IC50 =1.14 nM) and potently degrades ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). Most importantly, the introduction of the boronic acid group confers superior oral bioavailability of GLL398 (AUC = 36.9 μg·h/mL) in rats as compared to GW7604 (AUC = 3.35 μg·h/mL). The strikingly favorable pharmacokinetic property of GLL398 makes it a promising oral SERD suitable for clinical evaluation.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 120 Same day
10mg USD 190 Same day
25mg USD 350 Same day
50mg USD 550 Same day
100mg USD 950 Same day
200mg USD 1750 Same day
500mg USD 3850 Same day
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

GLL398 (mixture of E and Z-isomers), purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206771
Name: GLL398
CAS#: 2077980-83-5
Chemical Formula: C25H23BO4
Exact Mass: 398.1689
Molecular Weight: 398.265
Elemental Analysis: C, 75.40; H, 5.82; B, 2.71; O, 16.07


Synonym: GLL398; GLL-398; GLL 398.

IUPAC/Chemical Name: 3-(4-(1-(4-boronophenyl)-2-phenylbut-1-en-1-yl)phenyl)acrylic acid

InChi Key: BINZFDGAOTWQNC-VZBZSUMNSA-N

InChi Code: InChI=1S/C25H23BO4/c1-2-23(19-6-4-3-5-7-19)25(21-13-15-22(16-14-21)26(29)30)20-11-8-18(9-12-20)10-17-24(27)28/h3-17,29-30H,2H2,1H3,(H,27,28)/b17-10+,25-23-

SMILES Code: O=C(O)/C=C/C1=CC=C(/C(C2=CC=C(B(O)O)C=C2)=C(C3=CC=CC=C3)\CC)C=C1


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (contains E and Z isomers).

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Liu J, Zheng S, Guo S, Zhang C, Zhong Q, Zhang Q, Ma P, Skripnikova EV, Bratton MR, Wiese TE, Wang G. Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator. ACS Med Chem Lett. 2016 Nov 29;8(1):102-106. doi: 10.1021/acsmedchemlett.6b00410. eCollection 2017 Jan 12. PubMed PMID: 28105283; PubMed Central PMCID: PMC5238461.