Nafamostat mesylate
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MedKoo CAT#: 329453

CAS#: 82956-11-4 (mesylate)

Description: Nafamostat, also known as FUT-175, is a serine protease inhibitor and an anticoagulant. Nafamostat promotes endothelium-dependent vasorelaxation via the Akt-eNOS dependent pathway. Nafamostat Attenuates Ischemia-Reperfusion-Induced Renal Injury. Nafamostat Attenuates Ischemia-Reperfusion-Induced Renal Injury. Nafamostat protects against acute cerebral ischemia via blood-brain barrier protection. Nafamostat Inhibits TNF-α-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production. Researchers have identified the drug as a potential therapy for COVID-19,[ with clinical trials in Japan possibly set to begin in March 2020.


Price and Availability

Size Price Shipping out time Quantity
500mg USD 150 Same day
1g USD 250 Same day
2g USD 450 Same day
5g USD 750 Same day
10g USD 1450 Same day
20g USD 2250 2 Weeks
50g USD 3950 2 Weeks
100g USD 5850 2 Weeks
200g USD 8650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-11. Prices are subject to change without notice.

Nafamostat mesylate, purity > 98%, is in stock. The same day shipping after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 329453
Name: Nafamostat mesylate
CAS#: 82956-11-4 (mesylate)
Chemical Formula: C21H25N5O8S2
Exact Mass:
Molecular Weight: 539.578
Elemental Analysis: C, 46.75; H, 4.67; N, 12.98; O, 23.72; S, 11.88


Related CAS #: 81525-10-2 (free base)   82956-11-4 (mesylate)   80251-32-7 (HCl)    

Synonym: Nafamostat mesylate; nafamostat mesilate; FUT-175; FUT 175; FUT175.

IUPAC/Chemical Name: 6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate

InChi Key: SRXKIZXIRHMPFW-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)

SMILES Code: CS(=O)(O)=O.CS(=O)(O)=O.O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC(N)=N)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Related CAS#
81525-10-2 (Nafamostat free base
82956-11-4 (Nafamostat mesylate)


References

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2: Komi DEA, Redegeld FA. Role of Mast Cells in Shaping the Tumor Microenvironment. Clin Rev Allergy Immunol. 2019 Jun 29. doi: 10.1007/s12016-019-08753-w. Epub ahead of print. PMID: 31256327.

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11: Ribatti D, Ranieri G. Tryptase, a novel angiogenic factor stored in mast cell granules. Exp Cell Res. 2015 Mar 15;332(2):157-62. doi: 10.1016/j.yexcr.2014.11.014. Epub 2014 Dec 3. PMID: 25478999.

12: Marech I, Ammendola M, Gadaleta C, Zizzo N, Oakley C, Gadaleta CD, Ranieri G. Possible biological and translational significance of mast cells density in colorectal cancer. World J Gastroenterol. 2014 Jul 21;20(27):8910-20. doi: 10.3748/wjg.v20.i27.8910. PMID: 25083063; PMCID: PMC4112891.

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14: Ammendola M, Leporini C, Marech I, Gadaleta CD, Scognamillo G, Sacco R, Sammarco G, De Sarro G, Russo E, Ranieri G. Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy. Biomed Res Int. 2014;2014:154702. doi: 10.1155/2014/154702. Epub 2014 Sep 11. PMID: 25295247; PMCID: PMC4177740.

15: Wada H, Matsumoto T, Yamashita Y. [Recent therapeutic strategy for disseminated intravascular coagulation]. Rinsho Ketsueki. 2014 Jan;55(1):75-82. Japanese. PMID: 24492040.

16: Tauchi R, Imagama S, Ito Z, Ando K, Hirano K, Ukai J, Kobayashi K, Shinjo R, Muramoto A, Nakashima H, Matsumoto T, Ishiguro N. Acute pancreatitis after spine surgery: a case report and review of literature. Eur J Orthop Surg Traumatol. 2014 Jul;24 Suppl 1:S305-9. doi: 10.1007/s00590-013-1390-z. Epub 2013 Dec 8. PMID: 24318308.

17: Akshintala VS, Hutfless SM, Colantuoni E, Kim KJ, Khashab MA, Li T, Elmunzer BJ, Puhan MA, Sinha A, Kamal A, Lennon AM, Okolo PI, Palakurthy MK, Kalloo AN, Singh VK. Systematic review with network meta-analysis: pharmacological prophylaxis against post-ERCP pancreatitis. Aliment Pharmacol Ther. 2013 Dec;38(11-12):1325-37. doi: 10.1111/apt.12534. Epub 2013 Oct 20. PMID: 24138390.

18: Dhand A, Aminoff MJ. The neurology of itch. Brain. 2014 Feb;137(Pt 2):313-22. doi: 10.1093/brain/awt158. Epub 2013 Jun 22. PMID: 23794605.

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20: Yuhara H, Ogawa M, Kawaguchi Y, Igarashi M, Shimosegawa T, Mine T. Pharmacologic prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis: protease inhibitors and NSAIDs in a meta-analysis. J Gastroenterol. 2014 Mar;49(3):388-99. doi: 10.1007/s00535-013-0834-x. Epub 2013 May 30. PMID: 23720090.