LY-3177833
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206762

CAS#: 1627696-51-8

Description: LY-3177833 is a potent and selective inhibitor of CDC7 (Cell Division Cycle 7-related Protein Kinase).


Chemical Structure

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LY-3177833
CAS# 1627696-51-8

Theoretical Analysis

MedKoo Cat#: 206762
Name: LY-3177833
CAS#: 1627696-51-8
Chemical Formula: C16H12FN5O
Exact Mass: 309.1026
Molecular Weight: 309.3
Elemental Analysis: C, 62.13; H, 3.91; F, 6.14; N, 22.64; O, 5.17

Price and Availability

Size Price Availability Quantity
10.0mg USD 150.0 Same day
25.0mg USD 250.0 Same day
50.0mg USD 450.0 Same day
100.0mg USD 650.0 Same day
200.0mg USD 1150.0 Same day
500.0mg USD 2150.0 Same day
1.0g USD 3250.0 2 Weeks
2.0g USD 4850.0 2 Weeks
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Synonym: LY-3177833; LY 3177833; LY3177833.

IUPAC/Chemical Name: (3R)-3-(5-Fluoro-4-pyrimidinyl)-2,3-dihydro-3-methyl-6-(1H-pyrazol-4-yl)-1H-isoindol-1-one

InChi Key: KNLVLWZENYQYRT-MRXNPFEDSA-N

InChi Code: InChI=1S/C16H12FN5O/c1-16(14-13(17)7-18-8-19-14)12-3-2-9(10-5-20-21-6-10)4-11(12)15(23)22-16/h2-8H,1H3,(H,20,21)(H,22,23)/t16-/m1/s1

SMILES Code: O=C1N[C@@](C)(C2=NC=NC=C2F)C3=C1C=C(C4=CNN=C4)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Biological target: LY3177833 is a CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.0 96.99

Preparing Stock Solutions

The following data is based on the product molecular weight 309.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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