WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 329451
CAS#: 1054543-47-3
Description: Apoptozole, also known as Apoptosis Activator VII, is a selective inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 µM) that acts by blocking its ATPase activity. Apoptozole enhances immune responses to administered antigens. Treatment of mice with Apoptozole elicits production of antibodies with a high IgG2c/IgG1 ratio and stimulates the release of Th1 and Th2-type cytokines, suggesting that Apoptozole activates the Th1 and Th2 immune responses. The ATPase activities of Hsp70 and Hsc70 are known to be responsible for regulation of various biological processes.
MedKoo Cat#: 329451
Name: Apoptozole
CAS#: 1054543-47-3
Chemical Formula: C33H25F6N3O3
Exact Mass: 625.18
Molecular Weight: 625.5714
Elemental Analysis: C, 63.36; H, 4.03; F, 18.22; N, 6.72; O, 7.67
Synonym: Apoptozole; Apoptosis Activator VII.
IUPAC/Chemical Name: 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide
InChi Key: ZIMMTPFXOMAJTQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43)31(41-28)23-15-24(32(34,35)36)17-25(16-23)33(37,38)39/h3-17H,18H2,1-2H3,(H2,40,43)
SMILES Code: COC(C=C1)=CC=C1C2=C(C3=CC=C(OC)C=C3)N(CC4=CC=C(C(N)=O)C=C4)C(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=N2
1: Roundhill E, Turnbull D, Burchill S. Localization of MRP-1 to the outer mitochondrial membrane by the chaperone protein HSP90β. FASEB J. 2016 May;30(5):1712-23. doi: 10.1096/fj.15-283408. PubMed PMID: 26722004.
2: Baek KH, Zhang H, Lee BR, Kwon YG, Ha SJ, Shin I. A small molecule inhibitor for ATPase activity of Hsp70 and Hsc70 enhances the immune response to protein antigens. Sci Rep. 2015 Dec 3;5:17642. doi: 10.1038/srep17642. PubMed PMID: 26631605; PubMed Central PMCID: PMC4668564.
3: Evans LE, Cheeseman MD, Yahya N, Jones K. Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition. PLoS One. 2015 Oct 12;10(10):e0140006. doi: 10.1371/journal.pone.0140006. PubMed PMID: 26458144; PubMed Central PMCID: PMC4601772.
4: Ko SK, Kim J, Na DC, Park S, Park SH, Hyun JY, Baek KH, Kim ND, Kim NK, Park YN, Song K, Shin I. A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities. Chem Biol. 2015 Mar 19;22(3):391-403. doi: 10.1016/j.chembiol.2015.02.004. PubMed PMID: 25772468.
5: Cho HJ, Kim GH, Park SH, Hyun JY, Kim NK, Shin I. Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis. Mol Biosyst. 2015 Oct;11(10):2763-9. doi: 10.1039/c4mb00695j. PubMed PMID: 25728281.
6: Cho HJ, Gee HY, Baek KH, Ko SK, Park JM, Lee H, Kim ND, Lee MG, Shin I. A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator. J Am Chem Soc. 2011 Dec 21;133(50):20267-76. doi: 10.1021/ja206762p. PubMed PMID: 22074182.
