ONO-1714 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530422

CAS#: 214479-33-1 (HCl)

Description: ONO-1714 is a inducible nitric oxide synthase (NOS-2) inhibitor potentially for the treatment of hypotension. ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice. ONO-1714 reduces hyperoxic lung injury in mice. ONO-1714 inhibits neuronal NOS and exerts antinociception in rats.


Chemical Structure

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ONO-1714 HCl
CAS# 214479-33-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 530422
Name: ONO-1714 HCl
CAS#: 214479-33-1 (HCl)
Chemical Formula: C7H12Cl2N2
Exact Mass: 195.087
Molecular Weight:
Elemental Analysis: C, 43.10; H, 6.20; Cl, 36.34; N, 14.36

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ONO-1714 hydrochloride; ONO-1714; ONO 1714; ONO1714.

IUPAC/Chemical Name: (1S,5S,6R,7R)-7-Chloro-5-methyl-2-azabicyclo[4.1.0]heptan-3-imine hydrochloride

InChi Key: IZIZKGZAEABSET-IEUZAGAGSA-N

InChi Code: InChI=1S/C7H11ClN2.ClH/c1-3-2-4(9)10-7-5(3)6(7)8;/h3,5-7H,2H2,1H3,(H2,9,10);1H/t3-,5-,6+,7-;/m0./s1

SMILES Code: N=C1N[C@]2([H])[C@H](Cl)[C@]2([H])[C@@H](C)C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pozo-Rodrigálvarez A, Gradillas A, Serrano J, Fernández AP, Martínez-Murillo R, Pérez-Castells J. New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714. Eur J Med Chem. 2012 Aug;54:439-46. doi: 10.1016/j.ejmech.2012.05.031. PubMed PMID: 22703704.

2: Mishima T, Tajima Y, Kuroki T, Kosaka T, Adachi T, Kitasato A, Tsuneoka N, Kitajima T, Kanematsu T. Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters. Carcinogenesis. 2009 Oct;30(10):1763-7. doi: 10.1093/carcin/bgp194. PubMed PMID: 19696162.

3: Takahashi M, Kitahashi T, Ishigamori R, Mutoh M, Komiya M, Sato H, Kamanaka Y, Naka M, Maruyama T, Sugimura T, Wakabayashi K. Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor. Carcinogenesis. 2008 Aug;29(8):1608-13. doi: 10.1093/carcin/bgn152. PubMed PMID: 18567618.

4: Jiang BH, Maruyama J, Yokochi A, Mitani Y, Maruyama K. A novel inhibitor of inducible nitric oxide synthase, ONO-1714, does not ameliorate hypoxia-induced pulmonary hypertension in rats. Lung. 2007 Sep-Oct;185(5):303-8. PubMed PMID: 17721804.

5: Kohno H, Takahashi M, Yasui Y, Suzuki R, Miyamoto S, Kamanaka Y, Naka M, Maruyama T, Wakabayashi K, Tanaka T. A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice. Int J Cancer. 2007 Aug 1;121(3):506-13. PubMed PMID: 17417780.

6: Yuba T, Nagata K, Yamada T, Osugi S, Kuwahara H, Iwasaki Y, Handa O, Naito Y, Fushiki S, Yoshikawa T, Marunaka Y. A novel potent inhibitor of inducible nitric oxide synthase, ONO-1714, reduces hyperoxic lung injury in mice. Respir Med. 2007 Apr;101(4):793-9. PubMed PMID: 16982182.

7: Takahashi M, Mutoh M, Shoji Y, Sato H, Kamanaka Y, Naka M, Maruyama T, Sugimura T, Wakabayashi K. Suppressive effect of an inducible nitric oxide inhibitor, ONO-1714, on AOM-induced rat colon carcinogenesis. Nitric Oxide. 2006 Mar;14(2):130-6. PubMed PMID: 16122953.

8: Kukita K, Katsuramaki T, Kikuchi H, Meguro M, Nagayama M, Kimura H, Isobe M, Hirata K. Remnant liver injury after hepatectomy with the pringle maneuver and its inhibition by an iNOS inhibitor (ONO-1714) in a pig model. J Surg Res. 2005 May 1;125(1):78-87. PubMed PMID: 15836854.

9: Nakashima S, Matsuyama Y, Yu Y, Katayama Y, Ito Z, Ishiguro N. Expression of GDNF in spinal cord injury and its repression by ONO-1714. Neuroreport. 2005 Jan 19;16(1):17-20. PubMed PMID: 15618882.

10: Komeno M, Akimoto A, Fujita T, Katsube N. Effects of a selective inhibitor of inducible nitric oxide synthase, ONO-1714, on experimental hemodialysis-related hypotension in renal dysfunctional dogs. J Pharmacol Sci. 2004 Nov;96(3):343-6. PubMed PMID: 15539758.

11: Sekiguchi F, Mita Y, Kamanaka Y, Kawao N, Matsuya H, Taga C, Kawabata A. The potent inducible nitric oxide synthase inhibitor ONO-1714 inhibits neuronal NOS and exerts antinociception in rats. Neurosci Lett. 2004 Jul 22;365(2):111-5. PubMed PMID: 15245789.

12: Naito Y, Takagi T, Ichikawa H, Tomatsuri N, Kuroda M, Isozaki Y, Katada K, Uchiyama K, Kokura S, Yoshida N, Okanoue T, Yoshikawa T. A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide. 2004 May;10(3):170-7. PubMed PMID: 15158697.

13: Kamanaka Y, Kawabata A, Matsuya H, Taga C, Sekiguchi F, Kawao N. Effect of a potent iNOS inhibitor (ONO-1714) on acetaminophen-induced hepatotoxicity in the rat. Life Sci. 2003 Dec 26;74(6):793-802. PubMed PMID: 14654171.

14: Mikawa K, Nishina K, Takao Y, Obara H. ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits. Anesth Analg. 2003 Dec;97(6):1751-5. PubMed PMID: 14633554.

15: Shibuta S, Varathan S, Mashimo T. The neuroprotective effect of ONO-1714 on NMDA-mediated cytotoxicity in vitro. J Neurol Sci. 2003 Nov 15;215(1-2):31-6. PubMed PMID: 14568125.

16: Whittle BJ. ONO-1714 (Ono). IDrugs. 2002 Jun;5(6):590-3. PubMed PMID: 12802708.

17: Meguro M, Katsuramaki T, Kimura H, Isobe M, Nagayama M, Kukita K, Nui A, Hirata K. Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714. Transplantation. 2003 Mar 15;75(5):703-10. PubMed PMID: 12640313.

18: Meguro M, Katsuramaki T, Nagayama M, Kimura H, Isobe M, Kimura Y, Matsuno T, Nui A, Hirata K. A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver. Transplantation. 2002 May 15;73(9):1439-46. PubMed PMID: 12023622.

19: Mikawa K, Kodama SI, Nishina K, Obara H. ONO-1714, a new inducible nitric oxide synthase inhibitor, attenuates diaphragmatic dysfunction associated with cerulein-induced pancreatitis in rats. Crit Care Med. 2001 Jun;29(6):1215-21. PubMed PMID: 11395607.

20: Naito Y, Takagi T, Ishikawa T, Handa O, Matsumoto N, Yagi N, Matsuyama K, Yoshida N, Yoshikawa T. The inducible nitric oxide synthase inhibitor ONO-1714 blunts dextran sulfate sodium colitis in mice. Eur J Pharmacol. 2001 Jan 19;412(1):91-9. Erratum in: Eur J Pharmacol. 2012 Jun 5;684(1-3):168. PubMed PMID: 11166740.



Additional Information

Related CAS#
CAS No.
214478-65-6(ONO-1714 Free)
214479-33-1(ONO-1714 hydrochloride)