Nerispirdine HCl

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MedKoo CAT#: 328097

CAS#: 119229-64-0 (HCl)

Description: Nerispirdine, also known as HP-184, is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibited K(v)1.1 and K(v)1.2 with IC(50) values of 3.6 and 3.7 micromol/L, respectively. Nerispirdine also inhibited voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11.9 micromol/L when measured from a -70 mV holding potential.


Chemical Structure

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Nerispirdine HCl
CAS# 119229-64-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 328097
Name: Nerispirdine HCl
CAS#: 119229-64-0 (HCl)
Chemical Formula: C17H19ClFN3
Exact Mass: 0.00
Molecular Weight: 319.808
Elemental Analysis: C, 63.85; H, 5.99; Cl, 11.08; F, 5.94; N, 13.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Nerispirdine HCl; Nerispirdine hydrochloride; HP-184; HP 184; HP184.

IUPAC/Chemical Name: N-(3-fluoropyridin-4-yl)-3-methyl-N-propyl-1H-indol-1-amine hydrochloride

InChi Key: FYIIKHJFVLTAFI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18FN3.ClH/c1-3-10-20(17-8-9-19-11-15(17)18)21-12-13(2)14-6-4-5-7-16(14)21;/h4-9,11-12H,3,10H2,1-2H3;1H

SMILES Code: CCCN(C1=C(F)C=NC=C1)N2C=C(C)C3=C2C=CC=C3.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 119229-65-1 (Nerispirdine) 119229-64-0 (HP-184 or Nerispirdine hydrochloride)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 319.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Schofield J, Derdau V, Atzrodt J, Zane P, Guo Z, van Horn R, Czepczor V, Stoltz A, Pardon M. Effect of deuteration on metabolism and clearance of Nerispirdine (HP184) and AVE5638. Bioorg Med Chem. 2015 Jul 1;23(13):3831-42. doi: 10.1016/j.bmc.2015.03.065. PubMed PMID: 25900628.

2: Smith C, Kongsamut S, Wang H, Ji J, Kang J, Rampe D. In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin Exp Pharmacol Physiol. 2009 Nov;36(11):1104-9. doi: 10.1111/j.1440-1681.2009.05200.x. PubMed PMID: 19413590.

3: Smith CP, Woods-Kettelberger AT, Corbett R, Chesson SM, Bores GM, Petko WW, Roehr JE, Kongsamut S. Serotonergic activity of HP 184: does spontaneous release have a role? Neurochem Res. 1996 May;21(5):575-83. PubMed PMID: 8726966.

4: Tang L, Kongsamut S. Frequency-dependent inhibition of neurotransmitter release by besipirdine and HP 184. Eur J Pharmacol. 1996 Apr 4;300(1-2):71-4. PubMed PMID: 8741167.