Proxodolol hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328096

CAS#: 152289-59-3 (HCl)

Description: Proxodolol is a β-adrenergic receptor antagonist potentially for the treatment of glaucoma, hypertension and angina.

Chemical Structure

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Proxodolol hydrochloride
CAS# 152289-59-3 (HCl)
Instruction

Theoretical Analysis

MedKoo Cat#: 328096
Name: Proxodolol hydrochloride
CAS#: 152289-59-3 (HCl)
Chemical Formula: C17H26ClN3O4
Exact Mass: 0.00
Molecular Weight: 371.862
Elemental Analysis: C, 54.91; H, 7.05; Cl, 9.53; N, 11.30; O, 17.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Proxodolol hydrochloride;

IUPAC/Chemical Name: 1-(tert-butylamino)-3-(2-((3-methyl-1,2,4-oxadiazol-5-yl)methoxy)phenoxy)propan-2-ol hydrochloride

InChi Key: IJFQPJLVRULPKP-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H25N3O4.ClH/c1-12-19-16(24-20-12)11-23-15-8-6-5-7-14(15)22-10-13(21)9-18-17(2,3)4;/h5-8,13,18,21H,9-11H2,1-4H3;1H

SMILES Code: OC(COC1=CC=CC=C1OCC2=NC(C)=NO2)CNC(C)(C)C.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 152289-58-2 (Proxodolol Free) 152289-59-3 (Proxodolol hydrochloride)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 371.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Beliaeva SA. [Efficacy and safety of the first made in Russia αβ long-acting adrenoblocker proxodolol in patients with arterial hypertension of the second degree]. Ter Arkh. 2011;83(4):52-5. Russian. PubMed PMID: 21675275.

2: Shashurin DA, Timoshin AA, Medvedev OS, Vanin AF. [Effects of carvedilol and proxodolol on nitric oxide (NO) metabolism in various organs in a congestive heart failure model]. Eksp Klin Farmakol. 2011;74(1):19-23. Russian. PubMed PMID: 21476270.

3: Ol'binskaia LI, Sizova ZhM. [Efficacy and Safety of a Domestic Non-selective b-adrenoblocker Possibilities of the Use of Proxodolol in the Treatment of Patients With Chronic Heart Failure.]. Kardiologiia. 2006;46(12):17-20. Russian. PubMed PMID: 17310958.

4: Shashurin DA, Medvedev OS, Iuzhakov SD. [Studying the effect of the new beta-adrenoreceptor blocker proxodolol on the ischemic model of cardiac insufficiency]. Eksp Klin Farmakol. 2006 Mar-Apr;69(2):27-33. Russian. PubMed PMID: 16845936.

5: Iskenderov BG, Tatarchenko IP, Shevyrev VA. [Cardio-hemodynamic effects of domestic adrenergic beta-antagonist proxodolol in hypertension in patients with pacemaker]. Klin Med (Mosk). 1999;77(4):29-31. Russian. PubMed PMID: 10356914.

6: Ermakova VN, Malinina SL, Abdulkadyrova MZh, Filippova OM, Maliuta GD. [Therapy of patients with primary open-angle glaucoma with proxofelin, a combined form of proxodolol]. Vestn Oftalmol. 1999 Jan-Feb;115(1):3-5. Russian. PubMed PMID: 10207309.

7: Ermakova VN, Iuzhakov SD, Mashkovskiĭ MD, Kolomoĭtseva EM. [Proxodolol, a new domestic preparation for lowering intraocular pressure in glaucoma]. Vestn Oftalmol. 1995 Apr-Jun;111(2):4-7. Russian. PubMed PMID: 7645180.

8: Ermakova VN. [A clinico-pharmacological study of an ophthalmic drug form of proxodolol]. Eksp Klin Farmakol. 1994 May-Jun;57(3):57-9. Russian. PubMed PMID: 7914124.

9: Petrov IN, Rumiantsev AS, Smirnov MV. [The pharmacodynamics of proxodolol when administered once and in a course of doses to patients with stenocardia of effort]. Eksp Klin Farmakol. 1994 May-Jun;57(3):54-7. Russian. PubMed PMID: 7914123.

10: Bochkareva EV, Kokurina EV, Metelitsa VI, Pankina VA. [The comparative efficacy of individually adjusted doses of proxodolol and propranolol for one-time and regular administration in stenocardia patients]. Eksp Klin Farmakol. 1994 May-Jun;57(3):51-4. Russian. PubMed PMID: 7914122.

11: Metelitsa VI, Martsevich SIu, Kozyreva MP, Slastnikova ID, Vakulovskaia MK. [The efficacy of proxodolol, a new beta-adrenoblockader with alpha-adrenoblockader properties, in its single use in patients with stable stenocardia of effort]. Eksp Klin Farmakol. 1994 May-Jun;57(3):47-50. Russian. PubMed PMID: 7914121.

12: Kukes VG, Starodubtsev AK, Smirnov MV, Petrov IN. [The pharmacodynamic and hypotensive efficacy of proxodolol in an acute drug test on hypertension patients]. Eksp Klin Farmakol. 1994 May-Jun;57(3):45-7. Russian. PubMed PMID: 7914120.

13: Ol'binskaia LI, Morozova TE. [The new Russian preparation proxodolol in the treatment of arterial hypertension]. Eksp Klin Farmakol. 1994 May-Jun;57(3):42-5. Russian. PubMed PMID: 7914119.

14: Metelitsa VI, Ostrovskaia TP, Duda SG, Shastun RS, Chel'dieva EIa, Simonov DV, Kalinin AL, Kekshina MS. [The efficacy of proxodolol in patients with stable arterial hypertension]. Eksp Klin Farmakol. 1994 May-Jun;57(3):38-42. Russian. PubMed PMID: 7914118.

15: Rumiantsev DO, Piotrovskiĭ VK, Metelitsa VI, Golovanova IV, Ermachenkov IA, Gus'kova TA. [Proxodolol pharmacokinetics in rats and rabbits]. Eksp Klin Farmakol. 1994 May-Jun;57(3):36-8. Russian. PubMed PMID: 7914117.

16: Dolgun OV, Martynova ER, Medvedev OS, Iuzhakov SD. [The effect of proxodolol on systemic and regional hemodynamics]. Eksp Klin Farmakol. 1994 May-Jun;57(3):33-6. Russian. PubMed PMID: 7914116.

17: Iuzhakov SD, Dolgun OV, Dorodnikova EV, Aniukhovskiĭ EP, Baldenkov GN, Rozenshtraukh LV, Medvedev OS, Mashkovskiĭ MD. [Proxodolol--a new beta- and alpha-adrenoblockader]. Eksp Klin Farmakol. 1994 May-Jun;57(3):30-3. Russian. PubMed PMID: 7914115.