Isovaleramide
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MedKoo CAT#: 328094

CAS#: 541-46-8

Description: Isovaleramide, also known as NPS-1776, is a drug potentially for the treatment of migraine.


Price and Availability

Size Price Shipping out time Quantity
1g USD 80 2 Weeks
2g USD 150 2 Weeks
5g USD 250 2 Weeks
10g USD 450 2 Weeks
20g USD 650 2 Weeks
50g USD 950 2 Weeks
100g USD 1450 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

Isovaleramide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 328094
Name: Isovaleramide
CAS#: 541-46-8
Chemical Formula: C5H11NO
Exact Mass: 101.0841
Molecular Weight: 101.149
Elemental Analysis: C, 59.37; H, 10.96; N, 13.85; O, 15.82


Synonym: NPS-1776; NPS 1776; NPS1776; Isovaleramide.

IUPAC/Chemical Name: 3-Methylbutanamide

InChi Key: SANOUVWGPVYVAV-UHFFFAOYSA-N

InChi Code: InChI=1S/C5H11NO/c1-4(2)3-5(6)7/h4H,3H2,1-2H3,(H2,6,7)

SMILES Code: CC(C)CC(N)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Giraldo SE, Rincón J, Puebla P, Marder M, Wasowski C, Vergel N, Guerrero MF. [Isovaleramide, an anticonvulsant molecule isolated from Valeriana pavonii]. Biomedica. 2010 Apr-Jun;30(2):245-50. Spanish. PubMed PMID: 20890571.

2: Bialer M. New antiepileptic drugs that are second generation to existing antiepileptic drugs. Expert Opin Investig Drugs. 2006 Jun;15(6):637-47. Review. PubMed PMID: 16732716.

3: Rogawski MA. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Res. 2006 Jun;69(3):273-94. Review. PubMed PMID: 16621450; PubMed Central PMCID: PMC1562526.

4: Eadie MJ. Could valerian have been the first anticonvulsant? Epilepsia. 2004 Nov;45(11):1338-43. PubMed PMID: 15509234.

5: Isoherranen N, Yagen B, Bialer M. New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet? Curr Opin Neurol. 2003 Apr;16(2):203-11. Review. PubMed PMID: 12644750.

6: Kaylor JJ, Risley JM. Synthesis of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine analogues. n-Butyramide, 3-chloropropionamide, 3-aminopropionamide, and isovaleramide analogues. Carbohydr Res. 2001 Apr 23;331(4):439-44. PubMed PMID: 11398986.

7: Kozhemiakin LA, Zelenin KN, Bonitenko IuIu, Ivanova LI, Ershov AIu, Zemlianoĭ AV, Koroliuk MA. [Alcohol dehydrogenase inhibitors and their effect on major enzymatic systems involved in oxidation of aliphatic alcohols]. Vopr Med Khim. 1990 May-Jun;36(3):67-9. Russian. PubMed PMID: 2382435.

8: Chadha VK, Leidal KG, Plapp BV. Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism. J Med Chem. 1983 Jun;26(6):916-22. PubMed PMID: 6343601.

9: Galey WR, Owen JD, Solomon AK. Temperature dependence of nonelectrolyte permeation across red cell membranes. J Gen Physiol. 1973 Jun;61(6):727-46. PubMed PMID: 4708405; PubMed Central PMCID: PMC2203490.