L-771688

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530418

CAS#: 200050-59-5

Description: L-771688, also known as SNAP-6383, is an α1A-adrenoceptor antagonist potentially for the treatment of benign prostatic hyperplasia. L-771,688 had high affinity (Ki less than or = 1 nM) for [3H]prazosin binding to cloned human, rat and dog alpha1A-adrenoceptors and high selectivity (>500-fold) over alpha1B and alpha1D-adrenoceptors. L-771,688 is a highly selective alpha1A-adrenoceptor antagonist.


Chemical Structure

img
L-771688
CAS# 200050-59-5

Theoretical Analysis

MedKoo Cat#: 530418
Name: L-771688
CAS#: 200050-59-5
Chemical Formula: C28H33F2N5O5
Exact Mass: 557.245
Molecular Weight: 557.5988
Elemental Analysis: C, 60.31; H, 5.97; F, 6.81; N, 12.56; O, 14.35

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 200051-19-0 (dichloride);  

Synonym: L-771688; SNAP-6383; L 771688; SNAP 6383; L771688; SNAP6383.

IUPAC/Chemical Name: methyl (S)-4-(3,4-difluorophenyl)-6-(methoxymethyl)-2-oxo-3-((3-(4-(pyridin-2-yl)piperidin-1-yl)propyl)carbamoyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

InChi Key: FFXFCSQUTLDLAR-VWLOTQADSA-N

InChi Code: InChI=1S/C28H33F2N5O5/c1-39-17-23-24(26(36)40-2)25(19-7-8-20(29)21(30)16-19)35(28(38)33-23)27(37)32-12-5-13-34-14-9-18(10-15-34)22-6-3-4-11-31-22/h3-4,6-8,11,16,18,25H,5,9-10,12-15,17H2,1-2H3,(H,32,37)(H,33,38)/t25-/m0/s1

SMILES Code: O=C(C1=C(COC)NC(N(C(NCCCN2CCC(C3=NC=CC=C3)CC2)=O)[C@H]1C4=CC=C(F)C(F)=C4)=O)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 557.5988 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Xu F, Huang D, Lin X, Wang Y. Highly enantioselective Biginelli reaction
catalyzed by SPINOL-phosphoric acids. Org Biomol Chem. 2012 Jun
14;10(22):4467-70. doi: 10.1039/c2ob25663k. PubMed PMID: 22565820.

2: Li N, Chen XH, Song J, Luo SW, Fan W, Gong LZ. Highly enantioselective
organocatalytic Biginelli and Biginelli-like condensations: reversal of the
stereochemistry by tuning the 3,3'-disubstituents of phosphoric acids. J Am Chem
Soc. 2009 Oct 28;131(42):15301-10. doi: 10.1021/ja905320q. Erratum in: J Am Chem
Soc. 2010 Aug 11;132(31):10953. PubMed PMID: 19785440.

3: Winchell GA, Mistry GC, Kari PP, Marbury T, Miller JL, Simpson RC, Rodrigues
AD, Gottesdiener KM, Wagner JA. The effect of ketoconazole on the
pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist. J Clin
Pharmacol. 2005 Jun;45(6):699-703. PubMed PMID: 15901753.

4: Chang RS, Chen TB, O'Malley SS, Pettibone DJ, DiSalvo J, Francis B, Bock MG,
Freidinger R, Nagarathnam D, Miao SW, Shen Q, Lagu B, Murali Dhar TG, Tyagarajan
S, Marzabadi MR, Wong WC, Gluchowski C, Forray C. In vitro studies on L-771,688
(SNAP 6383), a new potent and selective alpha1A-adrenoceptor antagonist. Eur J
Pharmacol. 2000 Dec 15;409(3):301-12. PubMed PMID: 11108825.



Additional Information

Related CAS#
200050-59-5 (L-771688 free base)
200051-19-0 (L-771688 dihydrochloride)