SB 205384

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526259

CAS#: 160296-13-9

Description: SB 205384 is a GABAA receptor modulator. It potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). SB 205384 displays little effect on receptors containing α1 or α2 subunits.


Chemical Structure

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SB 205384
CAS# 160296-13-9

Theoretical Analysis

MedKoo Cat#: 526259
Name: SB 205384
CAS#: 160296-13-9
Chemical Formula: C17H18N2O3S
Exact Mass: 330.10
Molecular Weight: 330.400
Elemental Analysis: C, 61.80; H, 5.49; N, 8.48; O, 14.53; S, 9.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: SB 205384; SB-205384; SB205384.

IUPAC/Chemical Name: but-2-yn-1-yl (R)-4-amino-7-hydroxy-2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-b]pyridine-3-carboxylate

InChi Key: JDTZAGLGBRRCJT-SNVBAGLBSA-N

InChi Code: InChI=1S/C17H18N2O3S/c1-3-4-7-22-17(21)13-9(2)19-16-14(15(13)18)11-6-5-10(20)8-12(11)23-16/h10,20H,5-8H2,1-2H3,(H2,18,19)/t10-/m1/s1

SMILES Code: O=C(C1=C(C)N=C2C(C3=C(C[C@H](O)CC3)S2)=C1N)OCC#CC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 330.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Freitas J, Miller N, Mengeling BJ, Xia M, Huang R, Houck K, Rietjens IM, Furlow JD, Murk AJ. Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform. Curr Chem Genom Transl Med. 2014 Mar 7;8:36-46. doi: 10.2174/2213988501408010036. PubMed PMID: 24772387; PubMed Central PMCID: PMC3999704.

2: Heidelberg LS, Warren JW, Fisher JL. SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits. J Pharmacol Exp Ther. 2013 Oct;347(1):235-41. doi: 10.1124/jpet.113.207324. PubMed PMID: 23902941; PubMed Central PMCID: PMC3781410.

3: Chun SK, Jo YH. Loss of leptin receptors on hypothalamic POMC neurons alters synaptic inhibition. J Neurophysiol. 2010 Nov;104(5):2321-8. doi: 10.1152/jn.00371.2010. PubMed PMID: 20844117; PubMed Central PMCID: PMC2997019.

4: Miller BH, Schultz LE, Long BC, Pletcher MT. Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Mamm Genome. 2010 Jun;21(5-6):247-57. doi: 10.1007/s00335-010-9266-6. PubMed PMID: 20512339; PubMed Central PMCID: PMC2890984.

5: Navarro JF, Burón E, Martín-López M. Effects of SB-205384, a positive modulator of alpha3-subunit-containing GABA-A receptors, on isolation-induced aggression in male mice. Psicothema. 2008 Feb;20(1):144-7. PubMed PMID: 18206077.

6: Ing T, Poulter MO. Diversity of GABA(A) receptor synaptic currents on individual pyramidal cortical neurons. Eur J Neurosci. 2007 Feb;25(3):723-34. PubMed PMID: 17313570.

7: Navarro JF, Burón E, Martín-López M. Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice. Psicothema. 2006 Feb;18(1):100-4. PubMed PMID: 17296016.

8: Hutcheon B, Morley P, Poulter MO. Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J Physiol. 2000 Jan 1;522 Pt 1:3-17. PubMed PMID: 10618148; PubMed Central PMCID: PMC2269740.

9: Meadows HJ, Kumar CS, Pritchett DB, Blackburn TP, Benham CD. SB-205384: a GABA(A) receptor modulator with novel mechanism of action that shows subunit selectivity. Br J Pharmacol. 1998 Mar;123(6):1253-9. PubMed PMID: 9559912; PubMed Central PMCID: PMC1565273.

10: Meadows HJ, Harries MH, Thompson M, Benham CD. Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br J Pharmacol. 1997 Aug;121(7):1334-8. PubMed PMID: 9257911; PubMed Central PMCID: PMC1564816.