Org-12962
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 530404

CAS#: 132834-56-1

Description: Org-12962 is a 5-HT 2C receptor agonist potentially for the treatment of depression.

Chemical Structure

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Org-12962
CAS# 132834-56-1
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 530404
Name: Org-12962
CAS#: 132834-56-1
Chemical Formula: C10H11ClF3N3
Exact Mass: 265.06
Molecular Weight: 265.664
Elemental Analysis: C, 45.21; H, 4.17; Cl, 13.34; F, 21.45; N, 15.82

Price and Availability

Size Price Availability Quantity
10mg USD 235
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Synonym: Org-12962; Org 12962; Org12962.

IUPAC/Chemical Name: 1-[6-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazine

InChi Key: QZYYPQAYSFBKPW-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H11ClF3N3/c11-9-7(10(12,13)14)1-2-8(16-9)17-5-3-15-4-6-17/h1-2,15H,3-6H2

SMILES Code: FC(C1=C(Cl)N=C(N2CCNCC2)C=C1)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC0 value of 7.01.
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 250.0 941.04

Preparing Stock Solutions

The following data is based on the product molecular weight 265.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Halford JC, Harrold JA, Lawton CL, Blundell JE. Serotonin (5-HT) drugs:
effects on appetite expression and use for the treatment of obesity. Curr Drug
Targets. 2005 Mar;6(2):201-13. Review. PubMed PMID: 15777190.


2: Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR,
Sheardown MJ. Functional characterization of agonists at recombinant human
5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol. 1999
Sep;128(1):13-20. PubMed PMID: 10498829; PubMed Central PMCID: PMC1571597.


3: Jenck F, Moreau JL, Berendsen HH, Boes M, Broekkamp CL, Martin JR, Wichmann J,
Van Delft AM. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a
model of panic-like anxiety in rats. Eur Neuropsychopharmacol. 1998
Aug;8(3):161-8. PubMed PMID: 9716307.