WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 526963
Description: ALS–8112 is a RSV replication inhibior. ALS–8112 is the parent molecule of ALS-8176, a first-in-class nucleoside analog prodrug effective in the clinic against respiratory syncytial virus (RSV) infection. The antiviral activity of ALS-8112 is mediated by its 5'-triphosphate metabolite (ALS-8112-TP, or 2'F-4'ClCH2-cytidine triphosphate) inhibiting the RNA polymerase activity of the RSV L-P protein complex through RNA chain termination.
MedKoo Cat#: 526963
Chemical Formula: C10H13ClFN3O4
Exact Mass: 293.0579
Molecular Weight: 293.6794
Elemental Analysis: C, 40.90; H, 4.46; Cl, 12.07; F, 6.47; N, 14.31; O, 21.79
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: ALS–8112; ALS8112; ALS 8112.
IUPAC/Chemical Name: 4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
InChi Key: AWSRKKBIPSQHOJ-IBCQBUCCSA-N
InChi Code: InChI=1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1
SMILES Code: OC[C@]1(CCl)[C@H]([C@@H](F)[C@H](N2C(N=C(C=C2)N)=O)O1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 293.6794 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Deval J, Fung A, Stevens SK, Jordan PC, Gromova T, Taylor JS, Hong J, Meng J,
Wang G, Dyatkina N, Prhavc M, Symons JA, Beigelman L. Biochemical Effect of
Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase. PLoS
One. 2016 May 10;11(5):e0154097. doi: 10.1371/journal.pone.0154097. PubMed PMID:
27163448; PubMed Central PMCID: PMC4862670.
2: Deval J, Hong J, Wang G, Taylor J, Smith LK, Fung A, Stevens SK, Liu H, Jin Z,
Dyatkina N, Prhavc M, Stoycheva AD, Serebryany V, Liu J, Smith DB, Tam Y, Zhang
Q, Moore ML, Fearns R, Chanda SM, Blatt LM, Symons JA, Beigelman L. Molecular
Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase
by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate. PLoS Pathog. 2015 Jun
22;11(6):e1004995. doi: 10.1371/journal.ppat.1004995. PubMed PMID: 26098424;
PubMed Central PMCID: PMC4476725.