ALS–8112

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526963

CAS#: 1445379-92-9

Description: ALS–8112 is a RSV replication inhibior. ALS–8112 is the parent molecule of ALS-8176, a first-in-class nucleoside analog prodrug effective in the clinic against respiratory syncytial virus (RSV) infection. The antiviral activity of ALS-8112 is mediated by its 5'-triphosphate metabolite (ALS-8112-TP, or 2'F-4'ClCH2-cytidine triphosphate) inhibiting the RNA polymerase activity of the RSV L-P protein complex through RNA chain termination.


Chemical Structure

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ALS–8112
CAS# 1445379-92-9

Theoretical Analysis

MedKoo Cat#: 526963
Name: ALS–8112
CAS#: 1445379-92-9
Chemical Formula: C10H13ClFN3O4
Exact Mass: 293.0579
Molecular Weight: 293.6794
Elemental Analysis: C, 40.90; H, 4.46; Cl, 12.07; F, 6.47; N, 14.31; O, 21.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ALS–8112; ALS8112; ALS 8112.

IUPAC/Chemical Name: 4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

InChi Key: AWSRKKBIPSQHOJ-IBCQBUCCSA-N

InChi Code: InChI=1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1

SMILES Code: OC[C@]1(CCl)[C@H]([C@@H](F)[C@H](N2C(N=C(C=C2)N)=O)O1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 293.6794 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Deval J, Fung A, Stevens SK, Jordan PC, Gromova T, Taylor JS, Hong J, Meng J,
Wang G, Dyatkina N, Prhavc M, Symons JA, Beigelman L. Biochemical Effect of
Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase. PLoS
One. 2016 May 10;11(5):e0154097. doi: 10.1371/journal.pone.0154097. PubMed PMID:
27163448; PubMed Central PMCID: PMC4862670.

2: Deval J, Hong J, Wang G, Taylor J, Smith LK, Fung A, Stevens SK, Liu H, Jin Z,
Dyatkina N, Prhavc M, Stoycheva AD, Serebryany V, Liu J, Smith DB, Tam Y, Zhang
Q, Moore ML, Fearns R, Chanda SM, Blatt LM, Symons JA, Beigelman L. Molecular
Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase
by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate. PLoS Pathog. 2015 Jun
22;11(6):e1004995. doi: 10.1371/journal.ppat.1004995. PubMed PMID: 26098424;
PubMed Central PMCID: PMC4476725.