Alpha-Mangostin, 98%

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MedKoo CAT#: 328054

CAS#: 6147-11-1

Description: Alpha-Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities. α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell. Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity.

Chemical Structure

Alpha-Mangostin, 98%
CAS# 6147-11-1

Theoretical Analysis

MedKoo Cat#: 328054
Name: Alpha-Mangostin, 98%
CAS#: 6147-11-1
Chemical Formula: C24H26O6
Exact Mass: 410.1729
Molecular Weight: 410.466
Elemental Analysis: C, 70.23; H, 6.38; O, 23.39

Price and Availability

Size Price Availability Quantity
1.0g USD 1050.0 2 Weeks
2.0g USD 1650.0 2 Weeks
5.0g USD 2250.0 2 Weeks
10.0g USD 2950.0 2 Weeks
20.0g USD 3650.0 2 Weeks
50.0g USD 4650.0 2 Weeks
100.0g USD 5790.0 2 Weeks
200.0g USD 7650.0 2 Weeks
500.0g USD 12650.0 2 Weeks
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Synonym: Alpha-Mangostin; NSC 139154; NSC 27593; NSC 30552; NSC139154; NSC27593; NSC30552.

IUPAC/Chemical Name: 3,6,8-Trihydroxy-2-methoxy-1,7-bis(3-methylbut-2-enyl)xanthen-9-one


InChi Code: InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3

SMILES Code: O=C1C2=C(OC3=C1C(O)=C(C/C=C(C)\C)C(O)=C3)C=C(O)C(OC)=C2C/C=C(C)\C

Appearance: Yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 410.466 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lee J, Kang JS, Choi BY, Keum YS. Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin. Biomol Ther (Seoul). 2016 Nov 1;24(6):604-609. doi: 10.4062/biomolther.2016.028. PubMed PMID: 27469143.

2: Lee KW, Ryu HW, Oh SS, Park S, Madhi H, Yoo J, Park KH, Kim KD. Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy. Exp Dermatol. 2016 Oct 7. doi: 10.1111/exd.13233. [Epub ahead of print] PubMed PMID: 27714857.

3: Verma RK, Yu W, Shrivastava A, Shankar S, Srivastava RK. α-Mangostin-encapsulated PLGA nanoparticles inhibit pancreatic carcinogenesis by targeting cancer stem cells in human, and transgenic (Kras(G12D), and Kras(G12D)/tp53R270H) mice. Sci Rep. 2016 Sep 14;6:32743. doi: 10.1038/srep32743. PubMed PMID: 27624879; PubMed Central PMCID: PMC5021984.

4: Guo M, Wang X, Lu X, Wang H, Brodelius PE. α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF. PLoS One. 2016 Sep 1;11(9):e0161566. doi: 10.1371/journal.pone.0161566. PubMed PMID: 27584012; PubMed Central PMCID: PMC5008840.

5: Phitaktim S, Chomnawang M, Sirichaiwetchakoon K, Dunkhunthod B, Hobbs G, Eumkeb G. Synergism and the mechanism of action of the combination of α-mangostin isolated from Garcinia mangostana L. and oxacillin against an oxacillin-resistant Staphylococcus saprophyticus. BMC Microbiol. 2016 Aug 26;16(1):195. doi: 10.1186/s12866-016-0814-4. PubMed PMID: 27566110; PubMed Central PMCID: PMC5002192.

6: Kwak HH, Kim IR, Kim HJ, Park BS, Yu SB. α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell. Evid Based Complement Alternat Med. 2016;2016:5352412. doi: 10.1155/2016/5352412. PubMed PMID: 27478478; PubMed Central PMCID: PMC4960343.

7: Nava Catorce M, Acero G, Pedraza-Chaverri J, Fragoso G, Govezensky T, Gevorkian G. Alpha-mangostin attenuates brain inflammation induced by peripheral lipopolysaccharide administration in C57BL/6J mice. J Neuroimmunol. 2016 Aug 15;297:20-7. doi: 10.1016/j.jneuroim.2016.05.008. PubMed PMID: 27397072.

8: Kaomongkolgit R, Jamdee K. Inhibitory effect of alpha-mangostin on Candida biofilms. Odontology. 2016 Jul 1. [Epub ahead of print] PubMed PMID: 27368963.

9: Lee D, Choi YO, Kim KH, Chin YW, Namgung H, Yamabe N, Jung K. Protective effect of α-mangostin against iodixanol-induced apoptotic damage in LLC-PK1 cells. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3806-9. doi: 10.1016/j.bmcl.2016.05.031. PubMed PMID: 27293071.

10: Mekseepralard C, Areebambud C, Suksamrarn S, Jariyapongskul A. Effects of Long-Term Alpha-mangostin Supplementation on Hyperglycemia and Insulin Resistance in Type 2 Diabetic Rats Induced by High Fat Diet and Low Dose Streptozotocin. J Med Assoc Thai. 2015 Nov;98 Suppl 10:S23-30. PubMed PMID: 27276829.

11: Willson CM, Grundmann O. In vitro assays in natural products research - a matter of concentration and relevance to in vivo administration using resveratrol, α-mangostin/γ-mangostin and xanthohumol as examples. Nat Prod Res. 2016 May 27:1-15. [Epub ahead of print] PubMed PMID: 27234135.

12: Xia Y, Li Y, Westover KD, Sun J, Chen H, Zhang J, Fisher DE. Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin. PLoS One. 2016 May 6;11(5):e0155217. doi: 10.1371/journal.pone.0155217. PubMed PMID: 27152946; PubMed Central PMCID: PMC4859503.

13: Xia Y, Chen J, Gong C, Chen H, Sun J. α-Mangostin, a Natural Agent, Enhances the Response of NRAS Mutant Melanoma to Retinoic Acid. Med Sci Monit. 2016 Apr 22;22:1360-7. PubMed PMID: 27104669; PubMed Central PMCID: PMC4844330.

14: Carvalho-Silva R, Pereira AC, Dos Santos Alves RP, Guecheva TN, Henriques JA, Brendel M, Pungartnik C, Rios-Santos F. DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha-Mangostin. Evid Based Complement Alternat Med. 2016;2016:3430405. doi: 10.1155/2016/3430405. PubMed PMID: 27042187; PubMed Central PMCID: PMC4799812.

15: Qiu S, Granet R, Mbakidi JP, Brégier F, Pouget C, Micallef L, Sothea-Ouk T, Leger DY, Liagre B, Chaleix V, Sol V. Delivery of tanshinone IIA and α-mangostin from gold/PEI/cyclodextrin nanoparticle platform designed for prostate cancer chemotherapy. Bioorg Med Chem Lett. 2016 May 15;26(10):2503-6. doi: 10.1016/j.bmcl.2016.03.097. PubMed PMID: 27040657.

16: Hu Z, Wang W, Ling J, Jiang C. α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity. Cell Mol Neurobiol. 2016 Jul;36(5):811-20. doi: 10.1007/s10571-015-0264-9. PubMed PMID: 27002719; PubMed Central PMCID: PMC4894924.

17: Lee HN, Jang HY, Kim HJ, Shin SA, Choo GS, Park YS, Kim SK, Jung JY. Antitumor and apoptosis-inducing effects of α-mangostin extracted from the pericarp of the mangosteen fruit (Garcinia mangostana L.)in YD-15 tongue mucoepidermoid carcinoma cells. Int J Mol Med. 2016 Apr;37(4):939-48. doi: 10.3892/ijmm.2016.2517. PubMed PMID: 26951885; PubMed Central PMCID: PMC4790674.

18: Franceschelli S, Pesce M, Ferrone A, Patruno A, Pasqualone L, Carlucci G, Ferrone V, Carlucci M, de Lutiis MA, Grilli A, Felaco M, Speranza L. A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway. J Cell Physiol. 2016 Nov;231(11):2439-51. doi: 10.1002/jcp.25348. PubMed PMID: 26895796.

19: Kritsanawong S, Innajak S, Imoto M, Watanapokasin R. Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells. Int J Oncol. 2016 May;48(5):2155-65. doi: 10.3892/ijo.2016.3399. PubMed PMID: 26892433.

20: Fang Y, Su T, Qiu X, Mao P, Xu Y, Hu Z, Zhang Y, Zheng X, Xie P, Liu Q. Protective effect of alpha-mangostin against oxidative stress induced-retinal cell death. Sci Rep. 2016 Feb 18;6:21018. doi: 10.1038/srep21018. PubMed PMID: 26888416; PubMed Central PMCID: PMC4757868.