Retelliptine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206749

CAS#: 72238-02-9

Description: Retelliptine, also known as BD-84; NSC-D-626717-W; SR-95325B (diHCl); SR-95325A (dimaleate); is a DNA topoisomerase II inhibitor potentially for the treatment of cancer.

Chemical Structure

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Retelliptine
CAS# 72238-02-9
Instruction

Theoretical Analysis

MedKoo Cat#: 206749
Name: Retelliptine
CAS#: 72238-02-9
Chemical Formula: C25H32N4O
Exact Mass: 404.26
Molecular Weight: 404.558
Elemental Analysis: C, 74.22; H, 7.97; N, 13.85; O, 3.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Retelliptine; BD-84; NSC-D-626717-W; SR-95325B (diHCl); SR-95325A (dimaleate)

IUPAC/Chemical Name: 1-((3-(Diethylamino)propyl)amino)-5,11-dimethyl-9-methoxy-6H-pyrido(4,3-b)carbazole

InChi Key: PAVKBQLPQCDVNI-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H32N4O/c1-6-29(7-2)14-8-12-26-25-23-17(4)22-20-15-18(30-5)9-10-21(20)28-24(22)16(3)19(23)11-13-27-25/h9-11,13,15,28H,6-8,12,14H2,1-5H3,(H,26,27)

SMILES Code: COC1=CC2=C(NC3=C2C(C)=C(C(NCCCN(CC)CC)=NC=C4)C4=C3C)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 404.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kattan J, Durand M, Droz JP, Mahjoubi M, Marino JP, Azab M. Phase I study of retelliptine dihydrochloride (SR 95325 B) using a single two-hour intravenous infusion schedule. Am J Clin Oncol. 1994 Jun;17(3):242-5. PubMed PMID: 8192111.

2: Langdon SP, Hendriks HR, Braakhuis BJ, Pratesi G, Berger DP, Fodstad O, Fiebig HH, Boven E. Preclinical phase II studies in human tumor xenografts: a European multicenter follow-up study. Ann Oncol. 1994 May;5(5):415-22. PubMed PMID: 8075048.

3: Maulard C, Urien S, Bastian G, Tillement JP. Binding of retelliptine, a new antitumoral agent, to serum proteins and erythrocytes. Biochem Pharmacol. 1990 Aug 15;40(4):895-8. PubMed PMID: 2386553.

4: Ono K, Nakane H, Barre-Sinoussi F, Chermann JC. Differential inhibition by an antitumoral drug 10-[gamma-diethylaminopropylamino]-6-methyl-5H-pyrido[3',4': 4,5]pyrrolo [2,3-G]isoquinoline (BD-40), a pyrido-pyrrolo-isoquinoline derivative, of in vitro DNA synthesis catalyzed by various DNA polymerases. Cancer Lett. 1990 May 15;51(1):59-65. PubMed PMID: 1692511.

5: Roy M, Monsarrat B, Cros S, Lecointe P, Rivalle C, Bisagni E. Cytochrome P-450-mediated O-demethylation of two ellipticine derivatives. Differential effect of the murine Ah locus phenotype. Drug Metab Dispos. 1985 Jul-Aug;13(4):497-502. PubMed PMID: 2863116.