WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526955

CAS#: 1256735-81-5

Description: IDX-375 is a HCV NS5B polymerase inhibitor potentially for the treatment of HCV infection.

Chemical Structure

CAS# 1256735-81-5

Theoretical Analysis

MedKoo Cat#: 526955
Name: IDX-375
CAS#: 1256735-81-5
Chemical Formula: C29H50N5O7PS
Exact Mass:
Molecular Weight: 643.7808
Elemental Analysis: C, 54.11; H, 7.83; N, 10.88; O, 17.40; P, 4.81; S, 4.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: IDX-375; IDX 375; IDX375.

IUPAC/Chemical Name: 2-hydroxy-N,N,N-trimethylethan-1-aminium 2-(tert-butyl)-1-(3,3-dimethylbutyl)-4-(1-(2-hydroxyethyl)-7-(methylsulfonamido)-1-oxido-4H-benzo[c][1,5,2]diazaphosphinin-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-olate


InChi Code: InChI=1S/C24H37N4O6PS.C5H14NO/c1-23(2,3)10-11-28-20(24(4,5)6)19(30)18(22(28)31)21-25-16-9-8-15(27-36(7,33)34)14-17(16)35(32,26-21)13-12-29;1-6(2,3)4-5-7/h8-9,14,20,27,29-30H,10-13H2,1-7H3,(H,25,26,32);7H,4-5H2,1-3H3/q;+1/p-1

SMILES Code: CS(NC1=CC(P(N=C(C2=C([O-])C(C(C)(C)C)N(CCC(C)(C)C)C2=O)N3)(CCO)=O)=C3C=C1)(=O)=O.C[N+](C)(C)CCO

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 643.7808 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Valese AC, Vitali L, Fett R, Micke GA, de Oliveira MA, Oliveira Costa AC. A
Rapid Method for Analysis of Phenylalanine in Cereal Products by MEKC-UV Using
LC/MS/MS as a Comparative Method. J AOAC Int. 2015 Nov-Dec;98(6):1632-9. doi:
10.5740/jaoacint.15-052. PubMed PMID: 26651576.

2: Vitali L, Della Betta F, Costa AC, Vaz FA, Oliveira MA, Vistuba JP, Fávere VT,
Micke GA. New multilayer coating using quaternary ammonium chitosan and
κ-carrageenan in capillary electrophoresis: application in fast analysis of
betaine and methionine. Talanta. 2014 Jun;123:45-53. doi:
10.1016/j.talanta.2014.01.047. PubMed PMID: 24725863.

3: de Bruijne J, van de Wetering de Rooij J, van Vliet AA, Zhou XJ, Temam MF,
Molles J, Chen J, Pietropaolo K, Sullivan-Bólyai JZ, Mayers D, Reesink HW.
First-in-human study of the pharmacokinetics and antiviral activity of IDX375, a
novel nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents
Chemother. 2012 Aug;56(8):4525-8. doi: 10.1128/AAC.00451-12. PubMed PMID:
22664976; PubMed Central PMCID: PMC3421546.

Additional Information

Related CAS#
1162666-75-2 (IDX-375 free)
1256735-81-5 (IDX-375 salt)