WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 526953
Description: R-82913, also known as 9-Cmbib; NSC 637653, 9-Cl-Tibo, is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold more potent than AZT-TP in the inhibition of HIV-1 reverse transcriptase in an assay. R82913 has no effect on the replication of HIV-2 in CEM cells and does not inhibit the reverse transcriptase from this virus.
MedKoo Cat#: 526953
Chemical Formula: C16H20ClN3S
Exact Mass: 321.1066
Molecular Weight: 321.867
Elemental Analysis: C, 59.71; H, 6.26; Cl, 11.01; N, 13.06; S, 9.96
Synonym: R-82913; R 82913; R82913. 9-Cmbib; NSC 637653, 9-Cl-Tibo.
IUPAC/Chemical Name: (S)-4-chloro-8-methyl-7-(3-methylbut-2-en-1-yl)-6,7,8,9-tetrahydro-2,7,9a-triazabenzo[cd]azulene-1(2H)-thione
InChi Key: RCSLUNOLLUVOOG-NSHDSACASA-N
InChi Code: InChI=1S/C16H20ClN3S/c1-10(2)4-5-19-9-12-6-13(17)7-14-15(12)20(8-11(19)3)16(21)18-14/h4,6-7,11H,5,8-9H2,1-3H3,(H,18,21)/t11-/m0/s1
SMILES Code: S=C1NC2=C(N1C[C@H](C)N(C/C=C(C)\C)C3)C3=CC(Cl)=C2
1: Vandamme AM, Debyser Z, Pauwels R, De Vreese K, Goubau P, Youle M, Gazzard B,
Stoffels PA, Cauwenbergh GF, Anne J, et al. Characterization of HIV-1 strains
isolated from patients treated with TIBO R82913. AIDS Res Hum Retroviruses. 1994
Jan;10(1):39-46. PubMed PMID: 7514016.
2: Geissler RG, Ganser A, Ottmann OG, Kojouharoff G, Reutzel P, Andries K,
Schellekens K, Hoelzer D. TIBO R82913, a new HIV-1 inhibiting agent, does not
inhibit hematopoietic progenitor cells. AIDS Res Hum Retroviruses. 1991
Dec;7(12):1021-3. PubMed PMID: 1812943.
3: White EL, Buckheit RW Jr, Ross LJ, Germany JM, Andries K, Pauwels R, Janssen
PA, Shannon WM, Chirigos MA. A TIBO derivative, R82913, is a potent inhibitor of
HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Res. 1991
Oct;16(3):257-66. PubMed PMID: 1725247.