T-2000

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 526946

CAS#: 97846-21-4

Description: T-2000, also known as DMMDPB, is a GABA receptor agonist potentially for the treatment of essential tremor.


Chemical Structure

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T-2000
CAS# 97846-21-4

Theoretical Analysis

MedKoo Cat#: 526946
Name: T-2000
CAS#: 97846-21-4
Chemical Formula: C20H20N2O5
Exact Mass: 368.1372
Molecular Weight: 368.389
Elemental Analysis: C, 65.21; H, 5.47; N, 7.60; O, 21.71

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: T-2000, T 2000, T2000, DMMDPB

IUPAC/Chemical Name: 1,3-Dimethoxymethyl-5,5-diphenylbarbituric acid

InChi Key: RRFBTKHQZRCRSS-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H20N2O5/c1-26-13-21-17(23)20(15-9-5-3-6-10-15,16-11-7-4-8-12-16)18(24)22(14-27-2)19(21)25/h3-12H,13-14H2,1-2H3

SMILES Code: O=C(N(COC)C(C1(C2=CC=CC=C2)C3=CC=CC=C3)=O)N(COC)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 368.389 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hadj Tahar A, Chuang R, Steeves T, Jog M, Lang A, Grimes D. Efficacy and safety of T2000 in older patients with essential tremor. Parkinsonism Relat Disord. 2013 Apr;19(4):485-6. doi: 10.1016/j.parkreldis.2012.11.014. PubMed PMID: 23254160.

2: Melmed C, Moros D, Rutman H. Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid). Mov Disord. 2007 Apr 15;22(5):723-7. PubMed PMID: 17265458.