WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 526946
CAS#: 97846-21-4
Description: T-2000, also known as DMMDPB, is a GABA receptor agonist potentially for the treatment of essential tremor.
MedKoo Cat#: 526946
Name: T-2000
CAS#: 97846-21-4
Chemical Formula: C20H20N2O5
Exact Mass: 368.1372
Molecular Weight: 368.389
Elemental Analysis: C, 65.21; H, 5.47; N, 7.60; O, 21.71
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: T-2000, T 2000, T2000, DMMDPB
IUPAC/Chemical Name: 1,3-Dimethoxymethyl-5,5-diphenylbarbituric acid
InChi Key: RRFBTKHQZRCRSS-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H20N2O5/c1-26-13-21-17(23)20(15-9-5-3-6-10-15,16-11-7-4-8-12-16)18(24)22(14-27-2)19(21)25/h3-12H,13-14H2,1-2H3
SMILES Code: O=C(N(COC)C(C1(C2=CC=CC=C2)C3=CC=CC=C3)=O)N(COC)C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 368.389 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hadj Tahar A, Chuang R, Steeves T, Jog M, Lang A, Grimes D. Efficacy and safety of T2000 in older patients with essential tremor. Parkinsonism Relat Disord. 2013 Apr;19(4):485-6. doi: 10.1016/j.parkreldis.2012.11.014. PubMed PMID: 23254160.
2: Melmed C, Moros D, Rutman H. Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid). Mov Disord. 2007 Apr 15;22(5):723-7. PubMed PMID: 17265458.
