Benidipine Hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329307

CAS#: 91599-74-5 (HCl)

Description: Benidipine Hydrochloride, also known as KW-3049 and Coniel, is a dihydropyridine calcium antagonist used to treat hypertension and angina pectoris. Benidipine Hydrochloride has been reported to reduce oxidative stress.

Price and Availability


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Benidipine Hydrochloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 329307
Name: Benidipine Hydrochloride
CAS#: 91599-74-5 (HCl)
Chemical Formula: C28H32ClN3O6
Exact Mass: 541.198
Molecular Weight: 542.029
Elemental Analysis: C, 62.05; H, 5.95; Cl, 6.54; N, 7.75; O, 17.71

Related CAS #: 105979-17-7 (free base)   91599-74-5 (HCl)  

Synonym: Benidipine Hydrochloride; KW-3049; KW 3049; KW3049; Coniel;

IUPAC/Chemical Name: 3-((R)-1-benzylpiperidin-3-yl) 5-methyl (R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride


InChi Code: InChI=1S/C28H31N3O6.ClH/c1-18-24(27(32)36-3)26(21-11-7-12-22(15-21)31(34)35)25(19(2)29-18)28(33)37-23-13-8-14-30(17-23)16-20-9-5-4-6-10-20;/h4-7,9-12,15,23,26,29H,8,13-14,16-17H2,1-3H3;1H/t23-,26-;/m1./s1

SMILES Code: O=C(C1=C(C)NC(C)=C(C(O[C@H]2CN(CC3=CC=CC=C3)CCC2)=O)[C@@H]1C4=CC=CC([N+]([O-])=O)=C4)OC.[H]Cl

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information


1: Choi NY, Choi H, Park HH, Lee EH, Yu HJ, Lee KY, Joo Lee Y, Koh SH. Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells. Brain Res. 2014 Mar 10;1551:1-12. doi: 10.1016/j.brainres.2014.01.016. PubMed PMID: 24440775.

2: Sasaki H, Kanai S, Oyama T, Miyashita Y, Yamamura S, Shirai K. Effect of combination therapy of benidipine hydrochloride and candesartan cilexetil on serum lipid metabolism and blood pressure in elderly hypertensive patients with type 2 diabetes mellitus. J Atheroscler Thromb. 2006 Jun;13(3):149-57. PubMed PMID: 16835470.

3: Suzuki O, Yoshida T, Tani S, Kato K, Yoneyama A, Hibino T, Yokoi K, Matsubara T. Antioxidative effects of benidipine hydrochloride in patients with hypertension independent of antihypertensive effects. Relationship between blood pressure and oxidative stress. Arzneimittelforschung. 2004;54(9):505-12. PubMed PMID: 15500196.

4: Akbayram S, Akgün C, Doğan M, Geylani H, Sarı N, Taşkın AG, Caksen H. Benidipine hydrochloride intoxication in a child. J Emerg Med. 2012 Jun;42(6):700-1. doi: 10.1016/j.jemermed.2010.05.085. PubMed PMID: 20851552.

5: Sakane N, Kotani K, Hioki C, Yoshida T, Kawada T. Up-regulation of muscle uncoupling protein 3 gene expression by calcium channel blocker, benidipine hydrochloride in rats. Endocr J. 2007 Dec;54(5):771-5. PubMed PMID: 17878603.

6: Fukamachi S, Sugita K, Nakamura M, Tokura Y. Cutaneous pseudolymphoma due to benidipine hydrochloride with massive infiltration of eosinophils. J Dermatol. 2011 Sep;38(9):935-7. PubMed PMID: 21998837.

7: Seino H, Miyaguchi S, Yamazaki T, Ota S, Yabe R, Suzuki S. Effect of benidipine hydrochloride, a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus. Analysis after switching from cilnidipine to benidipine. Arzneimittelforschung. 2007;57(8):526-31. PubMed PMID: 17915639.

8: Yao K, Nagashima K, Miki H. Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker. J Pharmacol Sci. 2006 Apr;100(4):243-61. Review. PubMed PMID: 16565579.

9: Nomura M, Nakaya Y, Uemura E, Sawa Y, Iga A, Kageyama N, Nakayama T, Kusunoki K, Kawano T, Katoh K, Okamoto H, Nishikado A, Saito K, Ito S. Effects of benidipine hydrochloride on autonomic nervous activity in hypertensive patients with high- and low-salt diets. Arzneimittelforschung. 2003;53(5):314-20. PubMed PMID: 12854358.

10: Hirono O, Fatema K, Nitobe J, Takeishi Y, Kaneko K, Shiga R, Kubota I. Long-term effects of benidipine hydrochloride on severe left ventricular hypertrophy and collagen metabolism in patients with essential hypertension. J Cardiol. 2002 Apr;39(4):195-204. PubMed PMID: 11977767.

11: Ueno H, Hara T, Ishi A, Shuto K. Effects of benidipine hydrochloride on cerebrovascular lesions in salt-loaded stroke-prone spontaneously hypertensive rats: evaluation by magnetic resonance imaging. Jpn J Pharmacol. 2000 Sep;84(1):56-62. PubMed PMID: 11043454.

12: Nakajima O, Akioka H, Miyazaki M. Effect of the calcium antagonist benidipine hydrochloride on 24-h ambulatory blood pressure in patients with mild to moderate hypertension in a double-blind study against placebo. Arzneimittelforschung. 2000 Jul;50(7):620-5. PubMed PMID: 10965418.

13: Sugawara H, Shiraiwa H, Otsuka M, Ueki A. [A case of primary aldosteronism presenting hypokalemic myopathy induced by benidipine hydrochloride; a dihydropyridine calcium channel blocker]. Rinsho Shinkeigaku. 2000 May;40(5):446-51. Review. Japanese. PubMed PMID: 11002726.

14: Tomoda F, Takata M, Kagitani S, Kinuno H, Yasumoto K, Tomita S, Inoue H. Effects of a novel calcium antagonist, benidipine hydrochloride, on platelet responsiveness to mental stress in patients with essential hypertension. J Cardiovasc Pharmacol. 1999 Aug;34(2):248-53. PubMed PMID: 10445676.

15: Shou I, Wang LN, Takahashi Y, Fukui M, Tomino Y. Effects of benidipine hydrochloride on antioxidant enzyme activity in stroke-prone spontaneous hypertensive rats (SHR-SP). J Clin Lab Anal. 1997;11(3):158-62. PubMed PMID: 9138105.