Imiloxan

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 328040

CAS#: 81167-16-0

Description: Imiloxan, also known as RS-21361, is an α2 adrenergic receptor antagonist potentially for the treatment of major depressive disorder.

Chemical Structure

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Imiloxan
CAS# 81167-16-0
Instruction

Theoretical Analysis

MedKoo Cat#: 328040
Name: Imiloxan
CAS#: 81167-16-0
Chemical Formula: C14H16N2O2
Exact Mass: 244.12
Molecular Weight: 244.294
Elemental Analysis: C, 68.83; H, 6.60; N, 11.47; O, 13.10

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Imiloxan; RS-21361; RS 21361; RS21361.

IUPAC/Chemical Name: 2-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-ethyl-1H-imidazole

InChi Key: UXABARREKCJULM-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H16N2O2/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11/h3-8,11H,2,9-10H2,1H3

SMILES Code: CCN1C=CN=C1CC2OC3=CC=CC=C3OC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Related CAS# 86710-23-8 (Imiloxan hydrochloride ) 81167-16-0 (Imiloxan free base)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 244.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fitch WL, Chen Y, Liu L, Paehler A, Young M. Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan. Drug Metab Lett. 2010 Apr;4(2):77-87. PubMed PMID: 20446913.

2: Takano Y, Takano M, Yaksh TL. The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. Eur J Pharmacol. 1992 Sep 4;219(3):465-8. PubMed PMID: 1358645.

3: Rush WR, Hall DJ, Graham DJ, Selby IA. The metabolism of imiloxan hydrochloride in healthy male volunteers. Xenobiotica. 1992 Feb;22(2):237-46. PubMed PMID: 1352928.

4: Michel AD, Loury DN, Whiting RL. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99(3):560-4. PubMed PMID: 1970500; PubMed Central PMCID: PMC1917331.