SAR-405
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MedKoo CAT#: 406844

CAS#: 1523406-39-4

Description: SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. Combining SAR405 with everolimus results in a significant synergy on the reduction of cell proliferation using renal tumor cells.


Price and Availability

Size Price Shipping out time Quantity
200mg USD 2650 2 Weeks
500mg USD 3950 2 Weeks
1g USD 5450 2 Weeks
2g USD 9650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-27. Prices are subject to change without notice.

SAR-405, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406844
Name: SAR-405
CAS#: 1523406-39-4
Chemical Formula: C19H21ClF3N5O2
Exact Mass: 443.1336
Molecular Weight: 443.8552
Elemental Analysis: C, 51.42; H, 4.77; Cl, 7.99; F, 12.84; N, 15.78; O, 7.21


Synonym: SAR-405; SAR 405; SAR405.

IUPAC/Chemical Name: (S)-9-((5-chloropyridin-3-yl)methyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

InChi Key: SPDQRCUBFSRAFI-DOMZBBRYSA-N

InChi Code: InChI=1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1

SMILES Code: O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC4=CC(Cl)=CN=C4)[C@H](C(F)(F)F)CCN31


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Pasquier B. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and
synergizes with MTOR inhibition in tumor cells. Autophagy. 2015 Apr
3;11(4):725-6. doi: 10.1080/15548627.2015.1033601. PubMed PMID: 25905679; PubMed
Central PMCID: PMC4502822.

2: Marsh T, Debnath J. Ironing out VPS34 inhibition. Nat Cell Biol. 2015
Jan;17(1):1-3. PubMed PMID: 25679028.

3: Ronan B, Flamand O, Vescovi L, Dureuil C, Durand L, Fassy F, Bachelot MF,
Lamberton A, Mathieu M, Bertrand T, Marquette JP, El-Ahmad Y, Filoche-Romme B,
Schio L, Garcia-Echeverria C, Goulaouic H, Pasquier B. A highly potent and
selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat Chem
Biol. 2014 Dec;10(12):1013-9. doi: 10.1038/nchembio.1681. Epub 2014 Oct 19.
PubMed PMID: 25326666.