Ribociclib HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206739

CAS#: 1211443-80-9 (HCl)

Description: Ribociclib hydrochloride is an potent and orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.

Price and Availability


USD 150
USD 1650

USD 350
USD 2650

USD 450
USD 4650

Ribociclib HCl, purity > 99%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 20g may be 2 weeks..

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 206739
Name: Ribociclib HCl
CAS#: 1211443-80-9 (HCl)
Chemical Formula: C23H31ClN8O
Exact Mass:
Molecular Weight: 471.006
Elemental Analysis: C, 58.65; H, 6.63; Cl, 7.53; N, 23.79; O, 3.40

Related CAS #: 1211441-98-3 (free base)   1211443-80-9 (HCl)   1374639-75-4 (succinate)    

Synonym: Ribociclib hydrochloride; LEE011; LEE-011. LEE 011.

IUPAC/Chemical Name: 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride


InChi Code: InChI=1S/C23H30N8O.ClH/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1H


Technical Data

Yellow solid powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information

Related CAS#
1211441-98-3 (Ribociclib free base)
1211443-80-9 (Ribociclib hydrochloride)
1374639-75-4 (Ribociclib succinate)


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