WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 526895
CAS#: 1222800-79-4
Description: ML-324, also known as CID-44143209, is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.ML-324 displays submicromolar inhibitory activity toward JMJD2E (in vitro) and possesses excellent in vitro ADME properties. ML324 displays excellent cell permeability providing an opportunity for more extensive cell-based studies of JMJD2 enzymes to be undertaken. In addition, ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression.
MedKoo Cat#: 526895
Name: ML-324
CAS#: 1222800-79-4
Chemical Formula: C21H23N3O2
Exact Mass: 349.179
Molecular Weight: 349.434
Elemental Analysis: C, 72.18; H, 6.63; N, 12.03; O, 9.16
Synonym: ML-324; ML 324; ML324; CID-44143209; CID 44143209; CID44143209.
IUPAC/Chemical Name: N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide
InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)
SMILES Code: O=C(NCCCN(C)C)C1=CC=C(C2=CC(O)=C3N=CC=CC3=C2)C=C1
1: Pathak SS, Maitra S, Chakravarty S, Kumar A. Histone Lysine Demethylases of
JMJD2 or KDM4 Family are Important Epigenetic Regulators in Reward Circuitry in
the Etiopathology of Depression. Neuropsychopharmacology. 2016 Oct 6. doi:
10.1038/npp.2016.231. PubMed PMID: 27711046.
2: Rai G, Kawamura A, Tumber A, Liang Y, Vogel JL, Arbuckle JH, Rose NR,
Dexheimer TS, Foley TL, King ON, Quinn A, Mott BT, Schofield CJ, Oppermann U,
Jadhav A, Simeonov A, Kristie TM, Maloney DJ. Discovery of ML324, a JMJD2
demethylase inhibitor with demonstrated antiviral activity. 2012 Dec 17 [updated
2013 Sep 16]. Probe Reports from the NIH Molecular Libraries Program [Internet].
Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
Available from http://www.ncbi.nlm.nih.gov/books/NBK169450/
PubMed PMID: 24260783.