p-Cymene

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 329101

CAS#: 99-87-6

Description: p-Cymene, also known as p-Cymol, is an plant-derived aromatic hydrocarbon used for the relief of pain in rheumatic conditions. p-Cymene has anti-hyperalgesic and anti-inflammatory properties.


Chemical Structure

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p-Cymene
CAS# 99-87-6

Theoretical Analysis

MedKoo Cat#: 329101
Name: p-Cymene
CAS#: 99-87-6
Chemical Formula: C10H14
Exact Mass: 134.11
Molecular Weight: 134.222
Elemental Analysis: C, 89.49; H, 10.51

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: p-Cymene; Dolcymene; p-Cymol; p Cymene; pCymene; p Cymol; p-Cymol;

IUPAC/Chemical Name: p-cymene

InChi Key: HFPZCAJZSCWRBC-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H14/c1-8(2)10-6-4-9(3)5-7-10/h4-8H,1-3H3

SMILES Code: CC(C1=CC=C(C)C=C1)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 134.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hu X, Chu Y, Ma G, Li W, Wang X, Mo H, Yin Q, Guo J, Ma X, Zhou S. Simultaneous determination of ascaridole, p-cymene and α-terpinene in rat plasma after oral administration of Chenopodium ambrosioides L. by GC-MS. Biomed Chromatogr. 2015 Nov;29(11):1682-6. doi: 10.1002/bmc.3479. Epub 2015 Apr 21. PubMed PMID: 25900777.

2: Bedjanian Y, Morin J, Romanias MN. Gas-Phase Reaction of Hydroxyl Radical with p-Cymene over an Extended Temperature Range. J Phys Chem A. 2015 Nov 12;119(45):11076-83. doi: 10.1021/acs.jpca.5b08478. Epub 2015 Oct 28. PubMed PMID: 26473634.

3: de Oliveira TM, de Carvalho RB, da Costa IH, de Oliveira GA, de Souza AA, de Lima SG, de Freitas RM. Evaluation of p-cymene, a natural antioxidant. Pharm Biol. 2015 Mar;53(3):423-8. doi: 10.3109/13880209.2014.923003. Epub 2014 Dec 4. PubMed PMID: 25471840.

4: Silva MT, Ribeiro FP, Medeiros MA, Sampaio PA, Silva YM, Silva MT, Quintans JS, Quintans-Júnior LJ, Ribeiro LA. The vasorelaxant effect of p-cymene in rat aorta involves potassium channels. ScientificWorldJournal. 2015;2015:458080. doi: 10.1155/2015/458080. Epub 2015 Jan 15. PubMed PMID: 25667938; PubMed Central PMCID: PMC4312567.

5: Bi YH, Duan ZQ, Du WY, Wang ZY. Improved synthesis of phosphatidylserine using bio-based solvents, limonene and p-cymene. Biotechnol Lett. 2015 Jan;37(1):115-9. doi: 10.1007/s10529-014-1646-7. Epub 2014 Sep 12. PubMed PMID: 25214218.

6: Dash MR, Srinivasulu G, Rajakumar B. Experimental and computational investigation on the gas phase reaction of p-cymene with Cl atoms. J Phys Chem A. 2015 Jan 29;119(4):559-70. doi: 10.1021/jp509800g. Epub 2015 Jan 17. PubMed PMID: 25547646.

7: Păunescu E, Nowak-Sliwinska P, Clavel CM, Scopelliti R, Griffioen AW, Dyson PJ. Anticancer Organometallic Osmium(II)-p-cymene Complexes. ChemMedChem. 2015 Sep;10(9):1539-47. doi: 10.1002/cmdc.201500221. Epub 2015 Jul 14. PubMed PMID: 26190176.

8: Strijkstra A, Trautwein K, Jarling R, Wöhlbrand L, Dörries M, Reinhardt R, Drozdowska M, Golding BT, Wilkes H, Rabus R. Anaerobic activation of p-cymene in denitrifying betaproteobacteria: methyl group hydroxylation versus addition to fumarate. Appl Environ Microbiol. 2014 Dec;80(24):7592-603. doi: 10.1128/AEM.02385-14. Epub 2014 Sep 26. PubMed PMID: 25261521; PubMed Central PMCID: PMC4249252.

9: Nowak-Sliwinska P, Clavel CM, Păunescu E, te Winkel MT, Griffioen AW, Dyson PJ. Antiangiogenic and Anticancer Properties of Bifunctional Ruthenium(II)-p-Cymene Complexes: Influence of Pendant Perfluorous Chains. Mol Pharm. 2015 Aug 3;12(8):3089-96. doi: 10.1021/acs.molpharmaceut.5b00417. Epub 2015 Jul 21. PubMed PMID: 26158308.

10: Matsuoka A, Sandoval CA, Uchiyama M, Noyori R, Naka H. Why p-Cymene? Conformational effect in asymmetric hydrogenation of aromatic ketones with a η(6) -arene/ruthenium(II) catalyst. Chem Asian J. 2015 Jan;10(1):112-5. doi: 10.1002/asia.201402979. Epub 2014 Oct 24. PubMed PMID: 25346097.

11: de Santana MF, Guimarães AG, Chaves DO, Silva JC, Bonjardim LR, de Lucca Júnior W, Ferro JN, Barreto Ede O, dos Santos FE, Soares MB, Villarreal CF, Quintans Jde S, Quintans-Júnior LJ. The anti-hyperalgesic and anti-inflammatory profiles of p-cymene: Evidence for the involvement of opioid system and cytokines. Pharm Biol. 2015;53(11):1583-90. doi: 10.3109/13880209.2014.993040. Epub 2015 Apr 9. PubMed PMID: 25856703.

12: Chen L, Zhao L, Zhang C, Lan Z. Protective effect of p-cymene on lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2014 Apr;37(2):358-64. doi: 10.1007/s10753-013-9747-3. PubMed PMID: 24085645.

13: Rainis G, Ternes W. Identification and characterization of dimeric oxidation products of p-cymene-2,3-diol isolated from Thymus vulgaris L. J Agric Food Chem. 2014 Jan 8;62(1):235-43. doi: 10.1021/jf404193y. Epub 2013 Dec 19. PubMed PMID: 24354309.

14: Shang X, Wang Y, Zhou X, Guo X, Dong S, Wang D, Zhang J, Pan H, Zhang Y, Miao X. Acaricidal activity of oregano oil and its major component, carvacrol, thymol and p-cymene against Psoroptes cuniculi in vitro and in vivo. Vet Parasitol. 2016 Aug 15;226:93-6. doi: 10.1016/j.vetpar.2016.07.001. Epub 2016 Jul 2. PubMed PMID: 27514892.

15: Alarcón P, Bohn B, Zetzsch C, Rayez MT, Rayez JC. Reversible addition of the OH radical to p-cymene in the gas phase: multiple adduct formation. Part 2. Phys Chem Chem Phys. 2014 Aug 28;16(32):17315-26. doi: 10.1039/c4cp02073a. Epub 2014 Jul 14. PubMed PMID: 25020144.